{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T01:29:06Z","timestamp":1789781346738,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>An improved understanding of the computed tomographic (CT) features for malignant versus benign oral tumors would be helpful for guiding prognosis and treatment planning decisions in dogs. This retrospective, multi\u2010center, observational study compared the CT features of malignant and benign tumors in 28 dogs with 31 oral masses. Malignant tumors were present in 20 dogs, including malignant melanoma (n = 14), squamous cell carcinoma (SCC, n = 4), adenocarcinoma (n = 1), and fibrosarcoma (n = 1). Eight dogs had benign tumors, including giant cell granuloma (n = 2), peripheral odontogenic fibroma (n = 2), acanthomatous ameloblastoma (n = 2), plasmacytoma (n = 1), and oncocytoma (n = 1). Common CT features of malignant tumors included heterogeneous enhancement, tumor invasion into the adjacent bone, tooth loss, and ipsilateral mandibular lymphadenopathy. Malignant tumors were significantly larger than benign tumors. Bone lysis was found in benign tumors (n = 4) such as acanthomatous ameloblastoma, giant cell granuloma, and plasmacytoma. The bone lysis was a well\u2010defined geographic area regardless of malignancy and tumor type. In periosteal reactions, amorphous patterns were seen in both malignant (n = 2) and benign tumors (n = 2); the latter subgroup also showed solid patterns. Bone expansion (n = 2) was identified in malignant melanoma and acanthomatous ameloblastoma. Findings supported a diagnosis of possible malignancy for dogs with oral tumors having the following CT characteristics: large size, heterogeneous contrast enhancement pattern, bone lysis, tooth loss, and ipsilateral lymphadenopathy. However, there was a considerable overlap of CT findings among the different types of oral tumors and between benign and malignant tumors. Histological evaluation therefore remains necessary for definitive diagnosis.<\/jats:p>","DOI":"10.1111\/vru.12996","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T07:16:05Z","timestamp":1625728565000},"page":"549-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["CT features of malignant and benign oral tumors in 28 dogs"],"prefix":"10.1111","volume":"62","author":[{"given":"Suhyun","family":"Lee","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine and BK21 Plus Project Team Chonnam National University  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjung","family":"Jang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and BK21 Plus Project Team Chonnam National University  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gahyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Haemaru Referral Animal Hospital  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunghoon","family":"Jeon","sequence":"additional","affiliation":[{"name":"Joongang Animal Medical Center  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Yong Animal Medical Center  Changwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1258-7158","authenticated-orcid":false,"given":"Jihye","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and BK21 Plus Project Team Chonnam National University  Gwangju South 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