{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:56:02Z","timestamp":1789736162566,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of stereotactic body radiation therapy (SBRT) to treat many canine tumors is rapidly expanding. However, published studies are lacking regarding use of SBRT for management of canine anal sac adenocarcinoma (ASAC), primarily due to concerns regarding intolerable late effects. The objective of this retrospective, pilot study was to describe the efficacy and safety profile of coarse fractions administered with an SBRT regime to manage a group of dogs with ASAC. A total of 12 dogs with ASAC that received SBRT as a component of their treatment were sampled. Three patients had macroscopic primary tumors irradiated, while nine patients received SBRT following incomplete surgical resection. Seven patients also received metastatic regional lymph node irradiation. Primary tumor and nodal irradiation sites received three fractions totaling 22\u201024\u00a0Gy and 22.5\u201024\u00a0Gy, respectively, over three consecutive days. All patients developed acute effects including mild colitis, alopecia, and erythema. Late effects included alopecia, variable dermal pigmentation and leuko\u2010 or melanotrichia within radiation fields, and rectal stricture in one patient. A median progression free survival time of 549 days and median survival time of 991 days were achieved in this study. These results should be considered preliminary data suggesting that coarse fractionation administered with an SBRT technique is a safe and effective treatment regime for the management of canine ASAC, with the aim to conduct prospective studies in the future.<\/jats:p>","DOI":"10.1111\/vru.12998","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T08:09:58Z","timestamp":1623658198000},"page":"621-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pilot study evaluating the feasibility of stereotactic body radiation therapy for canine anal sac adenocarcinomas"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0769-4960","authenticated-orcid":false,"given":"Michaela","family":"Swan","sequence":"first","affiliation":[{"name":"Oncology Department Animal Referral Hospital  Homebush West New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanna","family":"Morrow","sequence":"additional","affiliation":[{"name":"Oncology Department Animal Referral Hospital  Homebush West New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Grace","sequence":"additional","affiliation":[{"name":"GenesisCare  Hurstville New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Adby","sequence":"additional","affiliation":[{"name":"Oncology Department Animal Referral Hospital  Homebush West New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lurie","sequence":"additional","affiliation":[{"name":"Oncology Department Animal Referral Hospital  Homebush West New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12671"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.1989.tb00787.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2002.tb01613.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2005.tb15626.x"},{"key":"e_1_2_11_6_1","first-page":"349","article-title":"Adenocarcinoma of the apocrine glands of the anal sac in dogs: a review of 32 cases","volume":"27","author":"Ross J","year":"1991","journal-title":"J Am Anim Hosp"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.223.825"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12410"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.253.1.84"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb02960.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2011.01907.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12226"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1476-5829.2003.00013.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.07.701"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12248"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12121"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2011.01186.x"},{"key":"e_1_2_11_18_1","first-page":"2136","volume-title":"ACVIM Forum Research Report Program","author":"ACVIM","year":"2018"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2008.04.001"},{"key":"e_1_2_11_20_1","first-page":"0","article-title":"Reducing margins for abdominopelvic tumours in dogs: impact on dose\u2010coverage and normal tissue complication probability","author":"Meier V","year":"2020","journal-title":"Vet Comp Oncol"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12032"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2001.tb00973.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1120\/jacmp.v12i2.3449"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.09.028"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.93.supplement_3.0219"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2002.tb01668.x"}],"container-title":["Veterinary Radiology &amp; 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