{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:07:45Z","timestamp":1785366465353,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T00:00:00Z","timestamp":1624147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lesions of the deep digital flexor tendon (DDFT) are a cause for foot lameness in horses. Positron emission tomography (PET) could provide valuable information regarding the metabolic activity of these lesions. The aims of this exploratory, prospective, methods comparison study were to assess the ability of <jats:sup>18<\/jats:sup>fluorine\u2010fluorodeoxyglucose (<jats:sup>18<\/jats:sup>F\u2010FDG) PET to detect DDFT lesions and to compare the PET findings with CT and MRI findings. Eight horses with lameness due to pain localized to the front feet were included. Both front limbs of all horses were imaged with <jats:sup>18<\/jats:sup>F\u2010FDG PET, noncontrast CT, and arterial contrast\u2010enhanced CT; 11 limbs were also assessed using MRI. Two observers graded independently <jats:sup>18<\/jats:sup>F\u2010FDG PET, noncontrast CT, arterial contrast CT, T1\u2010weighted (T1\u2010w) MRI, and T2\u2010weighted (T2\u2010w)\/STIR MRI. Maximal standardized uptake values were measured. Lesions were found in seven of 16 DDFT on PET, 12 of 16 DDFT on noncontrast CT, six of 15 DDFT on arterial contrast CT, eight of 11 DDFT on T1\u2010w MRI, and six of 11 DDFT on T2\u2010w\/STIR MRI. Positron emission tomography was in better agreement with arterial contrast CT (Kappa\u2010weighted 0.40) and T2\u2010w\/STIR MRI (0.35) than with noncontrast CT (0.28) and T1\u2010w MRI (0.20). Maximal standardized uptake values of lesions ranged from 1.9 to 4.6 with a median of 3.1. Chronic lesions with scar tissues identified on noncontrast CT or T1\u2010w MRI did not have increased <jats:sup>18<\/jats:sup>F\u2010FDG uptake. These results demonstrated that <jats:sup>18<\/jats:sup>F\u2010FDG PET agreed more closely with modalities previously used to detect active tendon lesions, i.e. arterial contrast CT and T2\u2010w\/STIR MRI. <jats:sup>18<\/jats:sup>Fluorine\u2010fluorodeoxyglucose PET can be used to identify metabolically active DDFT lesions in horses.<\/jats:p>","DOI":"10.1111\/vru.13001","type":"journal-article","created":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T15:14:05Z","timestamp":1624202045000},"page":"610-620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<sup>18<\/sup>Fluorine\u2010fluorodeoxyglucose positron emission tomography for assessment of deep digital flexor tendinopathy: An exploratory study in eight horses with comparison to CT and MRI"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0689-7133","authenticated-orcid":false,"given":"Sabrina","family":"Wilson","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9401-4857","authenticated-orcid":false,"given":"Mathieu","family":"Spriet","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4385-1000","authenticated-orcid":false,"given":"Pablo Espinosa","family":"Mur","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Anishchenko","sequence":"additional","affiliation":[{"name":"LONGMILE Veterinary Imaging Brain Biosciences Inc.  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