{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:33:08Z","timestamp":1767339188527},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Radioactive iodine is frequently used for staging of human thyroid carcinomas. Iodine\u2010124 scans performed using position emission tomography (PET) allow for more precise dosimetry of therapeutic radioiodine. The distribution of I\u2010124 has not previously been described in veterinary medicine. The purpose of this prospective, exporatory, descriptive study is to evaluate the whole\u2010body distribution of I\u2010124 in dogs with suspected thyroid carcinoma. Ten dogs with either a cytologic diagnosis of a neuroendocrine neoplasm or biochemical hyperthyroidism were enrolled in a prospective clinical study. Whole\u2010body I\u2010124 PET\/CT scans were performed and were evaluated for physiologic and pathologic uptake of I\u2010124. The maximum and mean standardized uptake values (SUVmean) were recorded for several normal and abnormal tissues. Varying degrees of uptake were found in thyroid tumors (SUVmean\u00a0=\u00a066.37), ectopic thyroid masses (21.44), presumed metastatic lesions in lymph nodes (32.14), and the pulmonary parenchyma (4.50). In most dogs, physiologic uptake above background, measured in maximum SUV, was identified in parotid and mandibular salivary glands (14.00 and 1.57) the urinary tract (1.83), the gastrointestinal tract (19.90 stomach, 6.15 colon), the liver (1.41), and the heart (1.88). Occasionally, uptake was identified in the nasolacrimal duct (3.42), salivary duct (2.73), gallbladder (2.68), and anal gland (2.22). Physiologic uptake was also identified in normal thyroid glands and ectopic thyroid tissue. This study provides a baseline of pathologic and physiologic uptake of I\u2010124 in dogs with thyroid carcinoma, to guide interpretation of future studies.<\/jats:p>","DOI":"10.1111\/vru.13050","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T03:28:41Z","timestamp":1639711721000},"page":"298-305","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Biodistribution and image characteristics of <sup>124<\/sup>I\u2010positron emission tomography in dogs with neuroendocrine neoplasia"],"prefix":"10.1111","volume":"63","author":[{"given":"Kate L.","family":"Shumway","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Surgery University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey N.","family":"Bryan","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay L.","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian K.","family":"Flesner","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy C.","family":"Lattimer","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela L.","family":"McCleary\u2010Wheeler","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joni M.","family":"Lunceford","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles A.","family":"Maitz","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.5326\/0460249"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2007.03.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12406"},{"key":"e_1_2_9_5_1","first-page":"177","article-title":"Ectopic thyroid carcinoma infiltrating the right atrium of the heart in a dog","volume":"53","author":"Kang M\u2010H","year":"2012","journal-title":"Can Vet J"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-59496-7.00026-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2007.03.008"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2001.tb00972.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2005.tb11650.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.229.4.542"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.216.1775"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12625"},{"key":"e_1_2_9_13_1","unstructured":"NusseyS WhiteheadS Endocrinology: An Integrated Approach. 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