{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:07:44Z","timestamp":1785366464222,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T00:00:00Z","timestamp":1658620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Maximal standardized uptake values (SUV<jats:sub>max<\/jats:sub>) are commonly used for the interpretation of PET studies. Limited information regarding the SUV<jats:sub>max<\/jats:sub> of <jats:sup>18<\/jats:sup>F\u2010NaF PET in horses is currently available in the literature. The goals of this retrospective secondary analysis study were to provide reference values for <jats:sup>18<\/jats:sup>F\u2010NaF SUV<jats:sub>max<\/jats:sub> in the equine distal extremity and assess the effect of attenuation correction. Nonattenuation corrected (NAC) and CT\u2010based attenuation corrected (CTAC) SUV<jats:sub>max<\/jats:sub> were obtained from 19 feet and 19 fetlocks. Twenty regions of interest (ROIs) were defined for the foot and 22 for the fetlock. Areas presenting abnormal uptake were excluded. The overall NAC and CTAC SUV<jats:sub>max<\/jats:sub> were 3.6 +\/\u2010 1.5 (mean +\/\u2010 sd) and 5.0 +\/\u2010 1.8 for the feet and 2.9 +\/\u2010 1.1 and 3.8 +\/\u2010 1.4 for the fetlocks, respectively. The 3 ROIs showing the highest attenuation correction were the navicular center (83.4%), navicular flexor surface (74.9%) and distal phalanx flexor surface (81.3%), whereas attenuation correction was only 5.2% at the dorsal aspect of the proximal phalanx. Significant SUV<jats:sub>max<\/jats:sub> differences were observed between the different ROIs (P\u00a0&lt;\u00a00.0001), with the toe (CTAC SUV<jats:sub>max<\/jats:sub> 7.7 +\/\u2010 3.7), dorsal (7.5 +\/\u2010 1.9) and central (6.1 +\/\u2010 2.2) ROIs of the distal phalanx being significantly higher than those of the other areas. This study demonstrates that attenuation correction affects SUVmax in the equine distal extremity and should be performed if CT data are available. However, as the maximal attenuation correction results in less than doubling the signal intensity, nonattenuation corrected images likely remain relevant for subjective clinical interpretation.<\/jats:p>","DOI":"10.1111\/vru.13127","type":"journal-article","created":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T17:43:56Z","timestamp":1658684636000},"page":"771-778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Standardized uptake values and attenuation correction in <sup>18<\/sup>F\u2010sodium fluoride PET of the equine foot and fetlock"],"prefix":"10.1111","volume":"63","author":[{"given":"Kimberley","family":"Sannajust","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine University of California Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9401-4857","authenticated-orcid":false,"given":"Mathieu","family":"Spriet","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine University of California Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Anishchenko","sequence":"additional","affiliation":[{"name":"LONGMILE Veterinary Imaging Brain Biosciences Inc.  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Beylin","sequence":"additional","affiliation":[{"name":"LONGMILE Veterinary Imaging Brain Biosciences Inc.  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.13299"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12719"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.13019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.189.3.8234714"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3413\/Nukmed-0867-16-12"},{"key":"e_1_2_9_7_1","first-page":"435","article-title":"Factors Affecting Uptake of NaF\u201018 by the Normal Skeleton","volume":"6","author":"Win AZ","year":"2014","journal-title":"J Clin Med Res"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108429"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000002533"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000633"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04424-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.13078"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/57\/9\/2477"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.13001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/50\/8\/014"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics2040042"},{"key":"e_1_2_9_17_1","volume-title":"Tables of X\u2010ray Mass Attenuation Coefficients and Mass Energy\u2010Absorption Coefficients","author":"Hubbel JH","year":"2001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12967"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.73.10.1589"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516401776563409"},{"key":"e_1_2_9_21_1","first-page":"342","volume-title":"Adams and Stashak's Lameness in Horses","author":"Selberg K","year":"2020"}],"container-title":["Veterinary Radiology &amp; Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vru.13127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vru.13127","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vru.13127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T17:01:09Z","timestamp":1692550869000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vru.13127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,24]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/vru.13127"],"URL":"https:\/\/doi.org\/10.1111\/vru.13127","archive":["Portico"],"relation":{},"ISSN":["1058-8183","1740-8261"],"issn-type":[{"value":"1058-8183","type":"print"},{"value":"1740-8261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,24]]},"assertion":[{"value":"2021-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}