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Computed tomography (CT) texture analysis can analyze the texture of images that the naive human eye cannot detect. Recently, there have been attempts to incorporate CT texture analysis with artificial intelligence in human medicine. This retrospective, analytical design study aimed to assess the feasibility of CT texture analysis in splenic masses and investigate predictive biomarkers of splenic hemangiosarcoma in dogs. Parameters for dogs with hemangiosarcoma and nodular hyperplasia were compared, and an independent parameter that could differentiate between them was selected. Discriminant analysis was performed to assess the ability to discriminate the two splenic masses and compare the relative importance of the parameters. A total of 23 dogs were sampled, including 16 splenic nodular hyperplasia and seven hemangiosarcoma. In each dog, total 38 radiomic parameters were extracted from first\u2010, second\u2010, and higher\u2010order matrices. Thirteen parameters had significant differences between hemangiosarcoma and nodular hyperplasia. Skewness in the first\u2010order matrix and GLRLM_LGRE and GLZLM_ZLNU in the second, higher\u2010order matrix were determined as independent parameters. A discriminant equation consisting of skewness, GLZLM_LGZE, and GLZLM_ZLNU was derived, and the cross\u2010validation verification result showed an accuracy of 95.7%. Skewness was the most influential parameter for the discrimination of the two masses. The study results supported using CT texture analysis to help differentiate hemangiosarcoma from nodular hyperplasia in dogs. This new diagnostic approach can be used for developing future machine learning\u2010based texture analysis tools.<\/jats:p>","DOI":"10.1111\/vru.13175","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T07:04:30Z","timestamp":1666767870000},"page":"224-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Can CT texture analysis parameters be used as imaging biomarkers for prediction of malignancy in canine splenic tumors?"],"prefix":"10.1111","volume":"64","author":[{"given":"Bo\u2010Kwon","family":"Choi","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Chonnam National University Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungjo","family":"Park","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Chonnam National University Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gahyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Haemaru Referral Animal Hospital Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongwoo","family":"Chang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Chungbuk National University Cheongju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunghoon","family":"Jeon","sequence":"additional","affiliation":[{"name":"Haemaru Referral Animal Hospital Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1258-7158","authenticated-orcid":false,"given":"Jihye","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Imaging, College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"307","volume-title":"Tumors in Domestic Animals","author":"Linder KE","year":"2017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2460\/javma.1992.200.06.829","article-title":"Prevalence, type, and importance of splenic diseases in dogs: 1,480 cases (1985\u20101989)","volume":"200","author":"Spangler WL","year":"1992","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_9_4_1","first-page":"639","volume-title":"Small animal clinical oncology","author":"Stephen JW","year":"2001"},{"key":"e_1_2_9_5_1","first-page":"457","article-title":"Canine hemangiosarcoma: A tumor of contemporary interest","volume":"6","author":"Helfand SC","year":"2008","journal-title":"Cancer Therapy"},{"key":"e_1_2_9_6_1","first-page":"250","article-title":"Splenic masses in dogs. 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