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Magnetic resonance imaging (MRI) features such as T2\u2010weighted spinal cord hyperintensity and loss of subarachnoid signal in a half\u2010Fourier single\u2010shot turbo spin echo (HASTE) sequence have been associated with PMM, but are sometimes present in other dogs with severe deficits. Magnetic resonance imaging findings in 22 dogs with a clinical or histopathologic diagnosis of PMM and 38 deep pain\u2010negative paraplegic dogs were compared in a retrospective case\u2010control study. Length of T2\u2010weighted hyperintense spinal cord change and HASTE signal loss were significantly associated with clinically evident PMM (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0019 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0085), however, there were no significant differences between groups when analysis was restricted to dogs not yet showing clinical signs of PMM. The PMM group also had significantly shorter compressive lesions than the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.026), suggesting a possible role of more severe focal pressure at the extrusion site. A segment of total loss of contrast enhancement in the venous sinuses and meninges, a feature not previously described, was more common in the PMM group and the difference approached significance (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.054). Findings show that MRI features can support the diagnosis in dogs with clinical evidence of PMM,\u00a0and\u00a0absence of these features supports absence of PMM at time of imaging. However, their absence\u00a0does not reliably differentiate dogs with imminent progressive myelomalacia from other dogs with severe deficits following intervertebral disc extrusion.<\/jats:p>","DOI":"10.1111\/vru.13178","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T08:25:40Z","timestamp":1674203140000},"page":"283-293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["MRI features can help to confirm a diagnosis of progressive myelomalacia, but may not be accurate in dogs lacking characteristic clinical signs at the time of imaging"],"prefix":"10.1111","volume":"64","author":[{"given":"Katelyn J.","family":"Cordle","sequence":"first","affiliation":[{"name":"Department of Molecular Biomedical Sciences College of Veterinary Medicine North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela S.","family":"Seiler","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences College of Veterinary Medicine North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Barnes","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences College of Veterinary Medicine North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha J.","family":"Olby","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1972.tb06870.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.237.10.1160"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2005.00109.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.04.003"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2013.04.003"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.222.762"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.241.12.1617"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13657"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.248.4.386"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14829"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13514"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13409"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-020-02690-z"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13423"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.12-0483"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15439"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1996.tb01371.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12463"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.1454"},{"key":"e_1_2_12_21_1","first-page":"959","article-title":"MR imaging of acute spinal cord injury: results of an experimental study in dogs","volume":"11","author":"Schouman\u2010Claeys E","year":"1990","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0393.x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/BSD.0b013e31823f2f55"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.234.4.495"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2015.09.018"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2006.00252.x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14656"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2014.244"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-019-2186-0"}],"container-title":["Veterinary Radiology &amp; 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