{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:43:33Z","timestamp":1791593013026,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteoarthritis of the elbow joint secondary to elbow dysplasia is common in dogs. Intraarticular radionuclide injection is thought to suppress both synovitis and inflammatory pain mediators in the joint which are not directly addressed by current treatments. This dose\u2010finding investigation was a longitudinal, prospective, experimental parallel group, post\u2010test study with repeated measures. Forty\u2010four dogs, with low to intermediate\u2010grade osteoarthritis, received a single injection into their most clinically affected elbow joint and were randomized into three treatment cohorts; 37 MBq, 64.75 MBq, or 92.5 MBq (normalized to the body surface area of a 22 kg dog) of<jats:sup>117m<\/jats:sup>Sn radiocolloid. Dogs were assessed monthly by owners, using the canine Brief Pain Inventory (cBPI), and at 1, 3, 6, 9, and 12 months intervals by investigators. Positive responses to treatment were observed by both owners and clinicians in all dose groups with the medium dose group having the highest and most durable response rate based on cBPI scores. The results of this study support the use of<jats:sup>117m<\/jats:sup>Sn radiocolloid as a primary treatment of osteoarthritis in low to intermediate\u2010grade osteoarthritis of the canine elbow.<\/jats:p>","DOI":"10.1111\/vru.13198","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T09:23:37Z","timestamp":1670837017000},"page":"351-359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical effectiveness and safety of intraarticular administration of a<sup>117m<\/sup>Tin radiocolloid (Synovetin OA<sup>TM<\/sup>) for treatment of early and intermediate grade osteoarthritis of the elbow in a dose finding study conducted in 44 dogs"],"prefix":"10.1111","volume":"64","author":[{"given":"Jimmy","family":"Lattimer","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Surgery University of Missouri Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Fabiani","sequence":"additional","affiliation":[{"name":"Gulf Coast Veterinary Specialists Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Gaschen","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Sciences Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karanvir","family":"Aulakh","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Sciences Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Selting","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine University of Illinois Urbana\u2010Champaign Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"https:\/\/www.ofa.org\/diseases\/elbow\u2010dysplasia accessed Mar 07 2021"},{"key":"e_1_2_10_3_1","unstructured":"https:\/\/www.akc.org\/expert\u2010advice\/news\/most\u2010popular\u2010dog\u2010breeds\u2010of\u20102018\/ accessed March 07 2021"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(00)50021-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100038\u20101677513"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201023940\u2010z"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.12.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2016.04.006"},{"issue":"1","key":"e_1_2_10_9_1","first-page":"49","article-title":"Osteoarthritis: diagnosis and treatment","volume":"85","author":"Sinusas K","year":"2012","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100038\u20101676293"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12508"},{"issue":"3","key":"e_1_2_10_12_1","first-page":"237","article-title":"Guidelines for safe and effective use of NSAIDs in dogs","volume":"6","author":"Lascelles BD","year":"2005","journal-title":"Vet Ther"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.5283"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12137"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.2012.00901.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-021-05541-7"},{"issue":"58","key":"e_1_2_10_17_1","first-page":"241","article-title":"Radiosynovectomy in Rheumatic Diseases","volume":"14","author":"\u0106wik\u0142a JB","year":"2014","journal-title":"J Ultraon"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010002\u20101058\u20100"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12757"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.233.8.1278"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.102435"},{"issue":"3","key":"e_1_2_10_22_1","first-page":"1243","article-title":"Homogeneous Sn\u2010117m Colloid Radiosynovectomy Results in Rat Models of Joint Disease","volume":"56","author":"Doerr C","year":"2015","journal-title":"J Nucl Med"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.147.12.325"},{"issue":"3","key":"e_1_2_10_24_1","first-page":"541","article-title":"Veterinary Clinics of North America: Small Animal","volume":"22","author":"Morgan SJ","year":"1992","journal-title":"Practice"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001466"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","unstructured":"DoomM deBruinT deRoosterH vanBreeH CoxE.Immunopathological mechanisms in dogs with rupture of the cranial cruciate ligament Vet Immunol Immunopathol.2008;125(1\u20102):143\u2010161.https:\/\/doi.org\/10.1016\/j.vetimm.2008.05.023","DOI":"10.1016\/j.vetimm.2008.05.023"},{"issue":"9","key":"e_1_2_10_27_1","first-page":"959","article-title":"A randomized blind placebo\u2010controlled trial investigating the effects of photobiomodulation therapy (PBMT) on canine elbow osteoarthritis","volume":"59","author":"Looney AL","year":"2018","journal-title":"Can Vet J"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.228.9.1350"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2017.07.002"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.67.4.654"},{"issue":"2","key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2460\/ajvr.1996.57.02.187","article-title":"Plasma, urine, and synovial fluid disposition of methylprednisolone acetate and isoflupredone acetate after intra\u2010articular administration in horses","volume":"57","author":"Lillich JD","year":"1996","journal-title":"Am J Vet Res"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS\u2010D\u201016\u201000808"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u20100813.1969.tb15103.x"},{"issue":"1","key":"e_1_2_10_34_1","first-page":"48S","article-title":"Radiosynovectomy in rheumatology, orthopedics, and hemophilia","volume":"46","author":"Schneider P","year":"2005","journal-title":"J Nucl Med"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1625120"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.2147\/VMRR.S295309"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/HP.000000000000122"}],"container-title":["Veterinary Radiology &amp; Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vru.13198","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vru.13198","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vru.13198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T06:18:17Z","timestamp":1728541097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vru.13198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,12]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/vru.13198"],"URL":"https:\/\/doi.org\/10.1111\/vru.13198","archive":["Portico"],"relation":{},"ISSN":["1058-8183","1740-8261"],"issn-type":[{"value":"1058-8183","type":"print"},{"value":"1740-8261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,12]]},"assertion":[{"value":"2022-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}