{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:49:45Z","timestamp":1790084985408,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two\u2010dimensional shear wave elastography (2D\u2010SWE) is widely used as a noninvasive method to quantify liver stiffness. In humans, liver stiffness approximates histologic hepatic fibrosis. While histology is the gold standard for diagnosing liver disease, 2D\u2010SWE may be a minimally invasive alternative to biopsy in feline patients. The objectives of this prospective, observational, crossover study were trifold: (1) to assess the feasibility of performing 2D\u2010SWE in awake cats, (2) to determine whether anesthesia altered shear wave velocity (SWV) measurements, and (3) to correlate hepatic stiffness with histologically quantified hepatic fibrosis. Eleven healthy, purpose\u2010bred cats underwent 2D\u2010SWE in awake and anesthetized states. SWV measurements were compared with histologic fibrosis measurements obtained from liver biopsies during the anesthetic period. The mean velocities were not significantly different between awake (1.47\u00a0\u00b1\u00a00.18\u00a0m\/s) and anesthetized (1.47\u00a0\u00b1\u00a00.24\u00a0m\/s) cats. Premedication and anesthetic drugs did not impact mean SWV. There was a higher variability in the SWV values in the awake group. The data points were reliably replicated, with an interquartile range of 0.24 and 0.32 in anesthetized and awake groups, respectively. There was moderate agreement between observers (intraclass correlation coefficient\u00a0=\u00a00.66). All cats had clinically insignificant fibrosis. There was no correlation between the SWV measurements and the histological fibrosis values. This study demonstrates that 2D\u2010SWE is feasible in awake cats and that the anesthetic protocol employed did not significantly alter mean SWV. This work is the first to histologically validate normal SWV values in cats and show that 2D\u2010SWE cannot differentiate minimal differences in feline hepatic fibrosis.<\/jats:p>","DOI":"10.1111\/vru.13267","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T07:05:41Z","timestamp":1689231941000},"page":"913-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Shear wave velocity values measured by 2D\u2010shear wave elastography are not different between awake and anesthetized cats without clinically significant hepatic fibrosis"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7602-8243","authenticated-orcid":false,"given":"Victoria","family":"Van","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0059-9060","authenticated-orcid":false,"given":"Nathalie","family":"Rademacher","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0723-8313","authenticated-orcid":false,"given":"Chin\u2010Chi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Keeton","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea N.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2013.01.022"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2013.01.024"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015150619"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.13508"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13516121"},{"key":"e_1_2_11_7_1","article-title":"Congenital hepatic fibrosis and polycystic kidney disease not linked to C >A mutation in exon 29 of PKD1 in a Persian cat","volume":"1","author":"Guerra JM","year":"2015","journal-title":"JFMS Open Rep"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317593"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrnm.2016.12.010"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021203893"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i46.6512"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15598"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.991148"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12969"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.5455\/javar.2020.g455"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.82.4.286"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/23144599.2022.2073138"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17204-5"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2018.07.008"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-211223"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2021.08.013"}],"container-title":["Veterinary Radiology &amp; 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