{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:17:05Z","timestamp":1776133025956,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Severe canine acute pancreatitis can be fatal; imaging features that can predict the clinical course of disease are useful for clinicians. On computed tomography (CT), both pancreatic heterogeneous contrast enhancement and portal vein thrombosis have been correlated with poorer outcome. Perfusion CT is used in human medicine to evaluate pancreatic microcirculation to predict the future development of severe sequela to pancreatitis; this technology has yet to be explored in dogs with acute pancreatitis. The objective of this prospective, case\u2010control study is to evaluate pancreatic perfusion using contrast\u2010enhanced CT in dogs with acute pancreatitis and compare it with previously established values obtained in healthy dogs. Ten client\u2010owned dogs preliminarily diagnosed with acute pancreatitis received a full abdominal ultrasound, specific canine pancreatic lipase (Spec cPL), and perfusion CT. Computer software calculated pancreatic perfusion, peak enhancement index, time to peak enhancement, and blood volume for 3\u2010mm and reformatted 6\u2010mm slices. The data was analyzed using Shapiro\u2013Wilk test, linear mixed model, and Spearman's rho. Values for 3\u2010mm slices were similar to 6\u2010mm slices (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Dogs with acute pancreatitis had a faster time to peak enhancement than healthy dogs (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04\u20130.06). Dogs with acute pancreatitis and homogeneous pancreatic enhancement had higher perfusion, faster time to peak enhancement, and greater blood volume compared to healthy dogs and dogs with acute pancreatitis and heterogeneous pancreatic enhancement (all <jats:italic>P<\/jats:italic>\u00a0=\u00a0\/\u00a0&lt;\u00a00.05). Pancreatic perfusion decreased with increased pancreatitis severity. No correlation was identified between Spec cPL and pancreatic perfusion (all <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). These findings preliminarily support perfusion CT in dogs with acute pancreatitis.<\/jats:p>","DOI":"10.1111\/vru.13272","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T12:54:21Z","timestamp":1687870461000},"page":"823-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Computed tomographic evaluation of pancreatic perfusion in 10 dogs with acute pancreatitis"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8021-3158","authenticated-orcid":false,"given":"Lauren","family":"von Stade","sequence":"first","affiliation":[{"name":"Department of Environmental and Radiologic Health Sciences Colorado State University Veterinary Teaching Hospital Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangeeta","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences Colorado State University Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0666-1435","authenticated-orcid":false,"given":"Angela J.","family":"Marolf","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences The Ohio State University College of Veterinary Medicine Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12274"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16292"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146965"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.07.014"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2012.04.003"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12467"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15364"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-014-0226-6"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5316"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.81.2.131"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.9.970"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2007.00251.x"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2006.00139.x"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00009952"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-011-9783-0"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15039"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2012.00951.x"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12158"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15693"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638715574862"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.13315"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2012.00893.x"}],"container-title":["Veterinary Radiology &amp; Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vru.13272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T01:41:06Z","timestamp":1694569266000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vru.13272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,27]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/vru.13272"],"URL":"https:\/\/doi.org\/10.1111\/vru.13272","archive":["Portico"],"relation":{},"ISSN":["1058-8183","1740-8261"],"issn-type":[{"value":"1058-8183","type":"print"},{"value":"1740-8261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,27]]},"assertion":[{"value":"2023-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}