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Based on our review of the literature, this is the first published study investigating whether needle size affects the diagnostic quality of hepatic and splenic samples. The aim of this prospective analytical study was to compare the diagnostic quality of ultrasound\u2010guided FNA cytological samples of canine liver and spleen based on cellularity, blood contamination, and overall cell preservation between three different needle sizes (22\u2010, 23\u2010, and 25\u2010gauge). A total of 282 splenic aspirates from 94 dogs and 348 hepatic aspirates from 116 dogs were enrolled in the study and examined by two board\u2010certified veterinary clinical pathologists. In this study, no significant differences in diagnostic quality were identified between different needle gauge sizes when sampling canine liver and spleen. Blood contamination was higher using 22\u2010gauge needles compared with 25\u2010gauge needles (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.024) when sampling the liver.<\/jats:p>","DOI":"10.1111\/vru.13290","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:29:28Z","timestamp":1691454568000},"page":"966-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic quality of ultrasound\u2010guided fine\u2010needle aspirates samples from the canine liver and spleen is not significantly affected by using 22\u2010, 23\u2010, and 25\u2010gauge needles"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7885-4079","authenticated-orcid":false,"given":"Cesar","family":"Llanos","sequence":"first","affiliation":[{"name":"Department of Clinical Science and Services Royal Veterinary College University of London Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Sciences Royal Veterinary College University of London Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7559-390X","authenticated-orcid":false,"given":"Crystal","family":"White","sequence":"additional","affiliation":[{"name":"Southfields Veterinary Specialists Essex UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Katherine","family":"Jasensky","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Sciences Royal Veterinary College University of London Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services Royal Veterinary College University of London Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12709"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1995.tb00233.x"},{"key":"e_1_2_12_4_1","first-page":"570","article-title":"Ultrasound\u2010guided liver fine needle biopsies in dogs; 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