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Referral radiographs and CT images demonstrated amorphous soft\u2010tissue and mineral opacities surrounding the proximal femur and the prosthetic stem, consistent with the \u201ccloud sign\u201d reported as a characteristic of metallosis in humans. Dorsomedial displacement of the prosthetic head, multiple foci of geographic osteolysis alongside the \u201ccloud sign\u201d, presumed pseudotumor lesions, and medial iliac lymphadenopathy were also identified with CT. Metallosis was confirmed based on ultrasound\u2010guided cytology, revision surgery, and histopathology.<\/jats:p>","DOI":"10.1111\/vru.13322","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T12:39:15Z","timestamp":1703248755000},"page":"49-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Radiographic and CT features of metallosis in a lame dog after total hip replacement: the cloud sign"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9324-4001","authenticated-orcid":false,"given":"Felix Daniel","family":"Lucaci","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine University of Agricultural Sciences and Veterinary Medicine  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0880-7944","authenticated-orcid":false,"given":"Pierantonio","family":"Battiato","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences University of Milan Lodi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Bassi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences University of Milan Lodi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0444-2784","authenticated-orcid":false,"given":"Davide Danilo","family":"Zani","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences University of Milan Lodi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7032-2297","authenticated-orcid":false,"given":"Donatella","family":"De Zani","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences University of Milan Lodi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2837-7822","authenticated-orcid":false,"given":"Aldo","family":"Vezzoni","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Vezzoni  Cremona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8529-572X","authenticated-orcid":false,"given":"Angelica","family":"Stranieri","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences University of Milan Lodi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6838-8430","authenticated-orcid":false,"given":"Maurizio","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences University of Milan Lodi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.324115183"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2484\/rcr.v2i4.115"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2484\/rcr.v5i2.410"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2017.01.002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.22467\/jwmr.2021.01732"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2012.01930.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.90B7.20213"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-015-2165-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12930"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985817716261"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12492"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3415\/VCOT-16-02-0028"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2016.07.001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199602)30:2<157::AID-JBM4>3.0.CO;2-Q"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-48247-9.00032-2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1997.tb03365.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-007-0362-y"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2019.04.010"},{"issue":"2","key":"e_1_2_6_20_1","first-page":"1","article-title":"Hip arthroplasty pseudotumors: pathogenesis, imaging, and clinical decision making","volume":"6","author":"Davis LD","year":"2016","journal-title":"J Clin Imag Sci"}],"container-title":["Veterinary Radiology &amp; 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