{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:42:53Z","timestamp":1789684973356,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Computed tomography is frequently used to stage canine mast cell tumors (MCTs). The aims of this prospective, observational study were to describe the CT features of MCTs, to evaluate the performance of CT in detecting additional or incidental MCTs, to distinguish between cutaneous (cMCT) or subcutaneous (scMCT) MCTs, and to identify one or multiple sentinel lymph nodes (SLNs) by indirect CT lymphography (ICTL). Seventy\u2010two dogs affected by 111 MCTs were included. The recorded parameters were: shape, size, attenuation (Hounsfield units [HU]), location (cutaneous or subcutaneous), and presence of fat stranding. The SLNs were compared with the regional lymph nodes and supplementary MCTs were registered. Mast cell tumors mostly appeared with well\u2010defined margins (89%), round\/oval shape (71%), homogeneous enhancement (90%) with a mean postcontrast density of 62.0\u00a0\u00b1\u00a023.4 HU and associated with fat stranding (43%). Cutaneous mast cell tumors were more frequently round (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.003), whereas scMCTs were oval (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.011) with a larger mean maximal diameter (2.91\u00a0\u00b1\u00a01.57\u00a0cm vs 1.46\u00a0\u00b1\u00a01.28\u00a0cm, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002) and more feeding vessels (77% vs 39% <jats:italic>P<\/jats:italic>\u00a0=\u00a0.044). Compared with histopathology, CT accuracy in differentiating cMCTs and sMCTs was 57%, with an interobserver agreement of 88% (three reviewers). Indirect CT lymphography showed the SLN in 82 of 85 (97%) cases, 32% of them not corresponding to the regional node. CT showed additional or incidental MCTs in 23 of 72 (32%) dogs. In conclusion, the common CT appearance of canine cMCTs and scMCTs is reported with some statistical differences between the two categories. CT is useful in identifying clinically undetected MCTs and SLNs, although it shows low accuracy in distinguishing between cMCT and scMCT.<\/jats:p>","DOI":"10.1111\/vru.13338","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T08:23:56Z","timestamp":1707553436000},"page":"170-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["CT features of cutaneous and subcutaneous canine mast cell tumors and utility of conventional and indirect lymphography to detect clinically unknown mast cell tumors and to map the sentinel lymph nodes"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8925-3291","authenticated-orcid":false,"given":"Beatrice","family":"Gianni","sequence":"first","affiliation":[{"name":"Anicura Clinica Veterinaria dell'Orologio Sasso Marconi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6797-397X","authenticated-orcid":false,"given":"Roberta","family":"Franchi","sequence":"additional","affiliation":[{"name":"Anicura Clinica Veterinaria dell'Orologio Sasso Marconi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0065-2952","authenticated-orcid":false,"given":"Mirko","family":"Mattolini","sequence":"additional","affiliation":[{"name":"Anicura Clinica Veterinaria dell'Orologio Sasso Marconi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Contiero","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine, Production and Health University of Padova Legnaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"Carozzi","sequence":"additional","affiliation":[{"name":"Anicura Clinica Veterinaria dell'Orologio Sasso Marconi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigia","family":"Nappi","sequence":"additional","affiliation":[{"name":"Anicura Centro Oncologico Veterinario Sasso Marconi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocchina","family":"Cammarota","sequence":"additional","affiliation":[{"name":"Anicura Clinica Veterinaria dell'Orologio Sasso Marconi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvanessa","family":"Caleri","sequence":"additional","affiliation":[{"name":"Anicura Clinica Veterinaria dell'Orologio Sasso Marconi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6402-930X","authenticated-orcid":false,"given":"Federica","family":"Rossi","sequence":"additional","affiliation":[{"name":"Anicura Clinica Veterinaria dell'Orologio Sasso Marconi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,10]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Withrow and MacEwen's Small Animal Clinical Oncology","author":"Vail DM","year":"2020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.755258"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810387446"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.13150"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.158.9.287"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.228.1.91"},{"key":"e_1_2_9_8_1","unstructured":"OwenLO TNM Classification of tumours in domestic animals. 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