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MRI identified moderate diffuse cerebral sulci widening, dilation of the ventricular system, and rounded, well\u2010defined, bilaterally symmetrical T2W, FLAIR, and T2* hyperintense intra\u2010axial lesions affecting the olivary nuclei. Histopathological examination was indicative of a primary mitochondrial disorder. This was confirmed following genetic analysis which identified mitochondrial fission encephalopathy with a homozygous frameshift variant in the <jats:italic>MFF<\/jats:italic> gene. This case report documents diagnostic imaging and histopathological findings not previously reported in dogs affected with mitochondrial fission encephalopathy, suggesting a different selective regional vulnerability of the neurons.<\/jats:p>","DOI":"10.1111\/vru.13342","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T07:28:35Z","timestamp":1714980515000},"page":"463-468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel MRI and histopathological findings in a young Bullmastiff cross dog with mitochondrial fission encephalopathy"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1775-6429","authenticated-orcid":false,"given":"Emma","family":"Suiter","sequence":"first","affiliation":[{"name":"Pride Veterinary Centre  Derby UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Baiker","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Science University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Kaczmarska","sequence":"additional","affiliation":[{"name":"Small Animal Hospital School of Biodiversity One Health and Veterinary Medicine University of Glasgow  Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Christen","sequence":"additional","affiliation":[{"name":"Institute of Genetics Vetsuisse Faculty University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tosso","family":"Leeb","sequence":"additional","affiliation":[{"name":"Institute of Genetics Vetsuisse Faculty University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Ororbia","sequence":"additional","affiliation":[{"name":"Pride Veterinary Centre  Derby UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Anselmi","sequence":"additional","affiliation":[{"name":"Pride Veterinary Centre  Derby UK"},{"name":"School of Veterinary Medicine and Science University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Minguez","sequence":"additional","affiliation":[{"name":"Pride Veterinary Centre  Derby UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3570-2542","authenticated-orcid":false,"given":"Rodrigo","family":"Gutierrez\u2010Quintana","sequence":"additional","affiliation":[{"name":"Small Animal Hospital School of Biodiversity One Health and Veterinary Medicine University of Glasgow  Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.13263"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.21741"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2001.tb00934.x"},{"volume-title":"Familial cerebellar ataxia in the Bull Mastiff","year":"1987","author":"Carmichael S","key":"e_1_2_9_5_1"},{"key":"e_1_2_9_6_1","first-page":"59","article-title":"Polioencephalomyelopathy in a mixed breed dog resembling Leigh's disease","volume":"56","author":"Chai O","year":"2015","journal-title":"Can Vet J"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050724"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2012.08.008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2008.07.013"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318244477d"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25789"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.676187"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.04.024"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00697000"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2009.00461.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201507035"}],"container-title":["Veterinary Radiology &amp; 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