{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:07:35Z","timestamp":1747188455222,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serial fluorine 18 fluorodeoxyglucose (<jats:sup>18<\/jats:sup>F\u2010FDG) positron emission tomography\u2013CT (PET\/CT) is commonly used in human oncology to prognosticate and evaluate for therapeutic effectiveness. In this pilot study, dogs with naturally occurring appendicular osteosarcoma were evaluated with serial <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT in an attempt to assess for response to therapy, prognostic factors, and appropriateness of imaging intervals. Fourteen dogs were enrolled in the trial. All dogs had the initial <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT (PET1), with nine dogs having their end\u2010of\u2010therapy <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT (EoT PET) 3 months after stereotactic body radiation therapy (SBRT) to the primary tumor. The median percent change from the PET1 to the EoT PET for the standard uptake value maximum (SUV<jats:sub>max%<\/jats:sub>) was \u221258% (range: \u221217 to \u221288%), metabolic tumor volume (MTV<jats:sub>%<\/jats:sub>) was \u221299.8% (range: \u221265 to \u2212100%), and total lesion glycolysis (TLG<jats:sub>%<\/jats:sub>) was \u221299.8% (range: \u221275 to \u2212100%), all of which were significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05, &lt;.05, and &lt;.05, respectively). On evaluation, it was found that volumes of GTV and CTV were significant for survival (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05 and &lt;.05), MTV<jats:sub>1<\/jats:sub>, TLG<jats:sub>1<\/jats:sub>, and SUV<jats:sub>max<\/jats:sub> on the EoT PET (SUV<jats:sub>maxEoT<\/jats:sub>) were predictive of metastasis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), and the SUV<jats:sub>max%<\/jats:sub> was significantly correlated to the time to first event (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Based on this data, serial <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT performed 3 months after SBRT can show a significant reduction in avidity, and the quantitative data collected may help predict metastatic disease in canine appendicular osteosarcoma.<\/jats:p>","DOI":"10.1111\/vru.13361","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T08:45:15Z","timestamp":1713948315000},"page":"408-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prospective pilot study utilizing changes in quantitative values obtained on serial fluorine\u201018 fluorodeoxyglucose (<sup>18<\/sup>F\u2010FDG) positron emission tomography\u2013computed tomography (PET\/CT) in dogs with appendicular osteosarcoma before and after stereotactic body radiation therapy (SBRT) and carboplatin chemotherapy to assess for prediction of survival and therapeutic effectiveness"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-4861","authenticated-orcid":false,"given":"Tiffany W.","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Flint Animal Cancer Center Colorado State University  Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0074-8233","authenticated-orcid":false,"given":"Lynn","family":"Griffin","sequence":"additional","affiliation":[{"name":"VCA Canada Central Victoria Veterinary Hospital  Victoria British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2961-x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13139-017-0493-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002319"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S259055"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.04.056"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13139-012-0181-5"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.117697"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-0397(99)00016-3"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.12453"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13906"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1333"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-016-0768-x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2020.05.001"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2012.01988.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2009.01520.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.13291"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12959"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-011-1936-4"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16388"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-6203.103606"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2741\/4696"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5488-5"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.13033"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15453"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12706"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12674"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.123.265592"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2474"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000000002"},{"key":"e_1_2_11_31_1","first-page":"1485","article-title":"PET studies of fluorodeoxyglucose metabolism in patients with recurrent colorectal tumors receiving radiotherapy","volume":"32","author":"Haberkorn U","year":"1991","journal-title":"J Nucl Med"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.01.012"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12351"}],"container-title":["Veterinary Radiology &amp; 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