{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:33:56Z","timestamp":1762432436341,"version":"3.40.5"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Malignant splenic lesions in dogs are common, with hemangiosarcoma diagnosed most frequently, and there have been no consistent clinicopathologic, gross, or imaging characteristics identified that differentiate malignant from benign splenic lesions. Histopathology is required for definitive diagnosis, and given the poor long\u2010term prognosis of malignant splenic lesions, a noninvasive tool to aid in diagnosis would be valuable. This prospective cohort study utilized gadoxetate disodium, a liver\u2010specific contrast agent (Gd\u2010EOB\u2010DPTA; Eovist), to identify the general lesion and pre\u2010 and postcontrast signal characteristics of benign and malignant splenic and hepatic lesions in dogs with naturally occurring disease. Twenty\u2010five dogs were enrolled, Eovist\u2010enhanced MRI was performed, and dogs were taken to surgery for splenectomy and other organ biopsy. All histopathology and MRI studies were evaluated by a single pathologist and a single radiologist, respectively. The associations between the tumor type and numerous variables defined on MRI were evaluated using Fisher's exact tests, and the significance was identified at a <jats:italic>P<\/jats:italic>\u2010value of\u00a0.05. Malignant splenic masses were identified in 11\/25 (44%) dogs, and 5\/11 malignancies represented hemangiosarcoma. The presence of abdominal effusion (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.017) and the presence of hepatic nodules on MRI (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.009) were associated with splenic malignancy. There were no benign T2 hyperintense and no malignant T2 hypointense lesions (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.021). Utilization of the T2 W MRI sequence may aid in the identification of malignant splenic lesions, particularly when accompanied by abdominal effusion and hepatic lesions.<\/jats:p>","DOI":"10.1111\/vru.13397","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T07:47:53Z","timestamp":1718869673000},"page":"556-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gadoxetate disodium (Gd\u2010EOB\u2010DTPA) contrast\u2010enhanced magnetic resonance imaging for differentiation between benign and malignant splenic lesions in dogs"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7778-6898","authenticated-orcid":false,"given":"Cassie N.","family":"Lux","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences University of Tennessee College of Veterinary Medicine  Knoxville Tennessee 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