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The aim was to evaluate the seventh cervical (C7) to second thoracic (T2) vertebrae in horses with neck\u2010related clinical signs (neck pain and\/or stiffness, neck\u2010related forelimb lameness, or general proprioceptive [spinal] ataxia) and control horses. This prospective analytical cross\u2010sectional study included 127 control horses and 96 cases, examined using standardized clinical and radiological protocols. Univariable logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) to identify factors associated with radiological abnormalities. Severe modeling of the articular processes at C7\u2013T1 was more likely in cases compared with controls, OR, 4.25; CI, 1.04\u201317.36; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04. Cases were more likely to have spondylolisthesis at C7\u2013T1 than controls, OR, 3.61; CI, 1.75\u20137.44; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001. There was a lack of uniformity of disc space width at C6\u2013C7, despite normal alignment of the vertebrae, in five (5.2%) cases and no control horses. Discospondylosis was seen in 9 (9.4%) horses at C7\u2013T1 and 10 of 64 (15.6%) at T1\u2013T2. The sagittal ratio for T1 was smaller for horses with neck\u2010related forelimb lameness (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0002), neck pain\/ stiffness (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04), or neurological cases (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) than controls. The prevalence of radiological abnormalities at C7\u2013T1 and T1\u2013T2 highlights the importance of careful evaluation of the cervicothoracic junction in horses with neck\u2010related signs.<\/jats:p>","DOI":"10.1111\/vru.13420","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T06:38:39Z","timestamp":1724135919000},"page":"755-768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Radiological abnormalities of the cervicothoracic vertebrae in Warmblood horses with primary neck\u2010related clinical signs versus controls"],"prefix":"10.1111","volume":"65","author":[{"given":"Sue","family":"Dyson","sequence":"first","affiliation":[{"name":"Animal Health Trust Kentford  Newmarket UK"},{"name":"Independent Consultant The Cottage  Market Weston 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