{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:04:01Z","timestamp":1773014641454,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In veterinary medicine, PET\/CT scans are generally performed with the patient under general anesthesia. The aim of this prospective crossover study was to compare the musculoskeletal uptake of\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FDG and radiation doses to workers during PET\/CT studies of healthy dogs and cats between sedation and general anesthesia. Volume and maximal standard uptake values (SUVmax) values of abnormal\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FDG uptake in the skeletal musculature, presence of misregistration artifact, and radiation doses to workers for each PET\/CT study were recorded. Sedation was associated with increased volume of\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FDG uptake in the musculature of the thoracic limbs (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.01), cervical (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.02), and thoracic (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.03) spine. Increased volume and SUVmax of the musculature assessed altogether were associated with the lighter degree of sedation (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.04 for both). A significant decrease in the odds of misregistration artifact was observed for anesthetized animals in comparison with sedated (OR: 0.0, 95% CI: 0.0\u20130.0,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.01). Radiation doses to workers were significantly higher for sedation compared with general anesthesia (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.01) and for the anesthesia technician compared with the nuclear medicine technologist (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.01). Use of sedation for PET\/CT studies in dogs and cats is feasible. However, it is associated with increased physiologic musculoskeletal uptake of\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FDG in the thoracic limbs, cervical, and thoracic spine, with increased frequency of misregistration artifact, and with increased radiation doses to workers. These limitations can be overcome by recognition of the uptake pattern and monitoring\/rotation of the involved staff at institutions where a high caseload is expected.\n                  <\/jats:p>","DOI":"10.1111\/vru.13439","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T15:57:53Z","timestamp":1728575873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of sedation and general anesthesia protocols for\n                    <sup>18<\/sup>\n                    F\u2010FDG\u2010PET\/CT studies in dogs and cats: Musculoskeletal uptake and radiation dose to workers"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6233-5656","authenticated-orcid":false,"given":"Alexandra F.","family":"Belotta","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences Western College of Veterinary Medicine, University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Beazley","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences Western College of Veterinary Medicine, University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Hutcheson","sequence":"additional","affiliation":[{"name":"Safety Resources University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0330-8767","authenticated-orcid":false,"given":"Monique","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences Western College of Veterinary Medicine, University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugues","family":"Beaufr\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Epidemiology UC Davis School of Veterinary Medicine  Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3952-5555","authenticated-orcid":false,"given":"Sally","family":"Sukut","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences Western College of Veterinary Medicine, University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2009.01612.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2010.01757.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2012.01925.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127800"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12959"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2016.00045"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12790"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12967"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12562"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.19.1.g99ja0761"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.295085247"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12138"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2015.12.008"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2012.01958.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.3659"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-197507000-00008"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2010.01727.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.13457"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2017.02.003"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.19.1.g99ja0761"},{"key":"e_1_2_11_22_1","first-page":"145","article-title":"18F\u2010FDG imaging: pitfalls and artifacts","volume":"33","author":"Abouzied MM","year":"2005","journal-title":"J Nuc Med Technol"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12015"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15456"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpet.2018.05.003"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2011.12.010"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X19847282"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2009.01636.x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12839"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.04.008"},{"key":"e_1_2_11_31_1","first-page":"246","article-title":"Effects of various anesthetic protocols on 18F\u2010flurodeoxyglucose uptake into the brains and hearts of normal miniature pigs (Sus scrofa domestica)","volume":"51","author":"Lee YA","year":"2012","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000531"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.4923"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2009.01562.x"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-010-0528-0"},{"key":"e_1_2_11_36_1","first-page":"107","article-title":"Radiation doses to technologists working with F\u201018\u2010FDG in a PET center with high patient capacity","volume":"55","author":"Demir M","year":"2010","journal-title":"Nukleonika"},{"key":"e_1_2_11_37_1","first-page":"2","article-title":"The 2007 recommendations of the International Comission on Radiological Protection, ICRP publication 103","volume":"37","author":"International Comission on Radiological Protection (ICRP)","year":"2007","journal-title":"Ann ICRP"}],"container-title":["Veterinary Radiology &amp; Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vru.13439","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vru.13439","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vru.13439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:54:06Z","timestamp":1773010446000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vru.13439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,10]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/vru.13439"],"URL":"https:\/\/doi.org\/10.1111\/vru.13439","archive":["Portico"],"relation":{},"ISSN":["1058-8183","1740-8261"],"issn-type":[{"value":"1058-8183","type":"print"},{"value":"1740-8261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,10]]},"assertion":[{"value":"2024-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13439"}}