{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:57:06Z","timestamp":1784876226705,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>There are few published descriptions of the MRI appearance of canine intracranial or spinal cord ependymoma. In this multicenter, retrospective, secondary analysis, case series study, three veterinary radiologists independently reviewed and recorded imaging characteristics of MRI studies in six dogs with histopathologically confirmed ependymoma (three intracranial and three spinal cord cases). A consensus was reached when there was disagreement on specific features. All intracranial ependymomas had forebrain location, heterogeneous signal intensity in T1\u2010weighted (T1W) and T2\u2010weighted (T2W) images, heterogeneous contrast enhancement, and hyperintensity in T2W images. Two ependymomas had an intraventricular location; one was intra\u2010axial. Other imaging features included intralesional cyst\u2010like structures, intralesional hemorrhage, and perilesional edema. Dogs with spinal cord ependymoma had intramedullary lesions located in the cervical or thoracic spinal cord. Spinal cord ependymomas were isointense and homogeneous in T1W images and hyperintense in T2W images. Lesion location relative to the central canal of the spinal cord was variable. All three spinal cord ependymomas had perilesional T2W hyperintensity and moderate, heterogeneous contrast enhancement. None of the spinal cord ependymomas had intralesional cyst\u2010like structures. One spinal cord ependymoma had evidence of drop metastases (diffuse, leptomeningeal). MRI features of canine ependymomas overlap with those of other diseases of the brain and spinal cord. Ependymoma should be considered a differential diagnosis for dogs with intraventricular, intra\u2010axial forebrain, or intramedullary spinal cord masses.<\/jats:p>","DOI":"10.1111\/vru.13477","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T23:36:53Z","timestamp":1734392213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["MRI findings in six dogs with ependymoma of the brain and spinal cord"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3943-7915","authenticated-orcid":false,"suffix":"IV","given":"John F","family":"Griffin","sequence":"first","affiliation":[{"name":"Department of Large Animal Clinical Sciences Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9147-6079","authenticated-orcid":false,"given":"William S","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Columbia Veterinary Emergency Trauma and Specialty  Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3765-1694","authenticated-orcid":false,"given":"Nathan C","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences College of Veterinary Medicine, North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie V","family":"Chen","sequence":"additional","affiliation":[{"name":"Veterinary Referral Center of Central Oregon  Bend Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8805-836X","authenticated-orcid":false,"given":"Silke","family":"Hecht","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences College of Veterinary Medicine, University of Tennessee  Knoxville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian F","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Elizabeth","family":"Boudreau","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swan","family":"Specchi","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Department AniCura Ospedale Veterinario \u201cI Portoni Rossi\u201d  Bologna Italy"},{"name":"Antech Imaging Services  Fountain Valley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bernardini","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Department AniCura Ospedale Veterinario \u201cI Portoni Rossi\u201d  Bologna Italy"},{"name":"Department of Animal Medicine Production and Health, University of Padua  Legnaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Mai","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine University of Pennsylvania School of Veterinary Medicine, Section of Radiology  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119181200.ch19"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985819859872"},{"key":"e_1_2_11_5_1","first-page":"211","volume-title":"Brain neoplasia. 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