{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:20:55Z","timestamp":1758846055500,"version":"3.44.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Echocardiography and radiography are frequently used to evaluate left atrial size, which serves as an important prognostic marker for canine cardiac conditions. However, there are no published criteria in veterinary medicine that allow for non\u2010ECG gated CT to detect the presence or absence of left atrial enlargement (LAE). The availability of a validated measurement of left atrial size would have the potential to improve the detection of cardiac disease in dogs having thoracic exams for non\u2010cardiovascular reasons. The objective of this study was to evaluate a non\u2010ECG gated CT left atrium\u2010to\u2010aortic diameter ratio (LA:Ao) for detecting LAE, while using a two\u2010dimensional (2D) echocardiogram as the gold standard. One hundred twenty\u2010three dogs that underwent thoracic non\u2010ECG gated CT and echocardiogram within 1 month of one another were evaluated retrospectively. Thirty\u2010three dogs were diagnosed with LAE on 2D echocardiogram (short axis LA:Ao \u2265 1.6) while 90 dogs had a normal left atrial size. The CT LA:Ao was not a sensitive discriminator for LAE in dogs; however, larger ratios were highly specific. Dogs with a CT LA:Ao \u2265 3.4 (97% specificity, 15% sensitivity, 71% PPV, and 76% NPV) may benefit from further evaluation with an echocardiogram at the discretion of the clinical care team. Overall, the method evaluated in this study was not able to reliably detect dogs that have echocardiographically confirmed LAE and, as such, appears to have low clinical utility. The use of multiplanar reconstructed images to emulate the right parasternal short\u2010axis plane is recommended for future studies.<\/jats:p>","DOI":"10.1111\/vru.70066","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T16:33:51Z","timestamp":1753547631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non\u2010ECG Gated Computed Tomographic Left Atrium\u2010to\u2010Aortic Diameter Ratio is not a Sensitive Discriminator for Detecting Left Atrial Enlargement in Dogs"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5082-9582","authenticated-orcid":false,"given":"Jake","family":"Johnson","sequence":"first","affiliation":[{"name":"Cummings School of Veterinary Medicine At Tufts University  North Grafton Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7998-6471","authenticated-orcid":false,"given":"Jenelle","family":"Soppet","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine At Tufts University  North Grafton Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Sutherland\u2010Smith","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine At Tufts University  North Grafton Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Sato","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine At Tufts University  North Grafton Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine At Tufts University  North Grafton Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keaton","family":"Cortez","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine At Tufts University  North Grafton Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agustina","family":"Anson","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine At Tufts University  North Grafton Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2012.01976.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2012.01.006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2012.02.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2003.tb02496.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2002.tb01051.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2000.tb02252.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1995.206.02.194"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16073"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.253.8.1038"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15854"},{"key":"e_1_2_10_12_1","unstructured":"J.Bouvard F.Thierry M.Longo et\u00a0al. \u201cComparison of ECG\u2010Gated Multidetector Computed Tomography and Two\u2010Dimensional Echocardiographic Methods in the Assessment of Left Atrial Size Using Left Atrial\u2010to\u2010Aortic Root Short\u2010Axis Ratio in Dogs \u201dPaper presented at: 28thECVIM\u2010CA Congress 2018; September2018;Rotterdam the Netherlands."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.81.1.33"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1993.tb01015.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yasa.2022.05.002"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-014-0242-3"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12976"},{"issue":"3","key":"e_1_2_10_18_1","first-page":"1127","article-title":"ACVIM Consensus Guidelines for the Diagnosis and Treatment of Myxomatous Mitral Valve Disease in Dogs","volume":"33","author":"Keene B. 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