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This study aims to compare the apparent diffusion coefficient (ADC) values of intracranial ring\u2010enhancing lesions of infectious etiology with ring\u2010enhancing lesions caused by other etiologies. Records were reviewed for MRI studies with diffusion\u2010weighted imaging (DWI) and post\u2010gadolinium T1\u2010weighted ring\u2010enhancing lesions with a definitive histopathological diagnosis or a microbiological diagnosis of brain infection. ADC maps were generated, and regions of interest were selected to evaluate ADC values of ring\u2010enhancing lesions. Normalized ADC values (rADC) were calculated using ADC values from lesional and contralateral brain regions of interest (rADC\u00a0=\u00a0ADC<jats:sub>lesion<\/jats:sub>\/ADC<jats:sub>CB<\/jats:sub>). A total of 69 cases met the inclusion criteria (68 dogs, 1 cat). Median (range) rADC was significantly lower for intraparenchymal bacterial abscesses [0.54 (0.19\u20130.82)] compared to ring\u2010enhancing gliomas [1.7 (0.80\u20133.9); <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0003) and non\u2010infectious inflammatory lesions [1.7 (0.74\u20133.3); <jats:italic>p<\/jats:italic>\u00a0=\u00a00.024], but not significantly different compared to intraparenchymal hemorrhage [0.54 (0.33\u20130.87); <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.99]. Extraparenchymal bacterial empyema and intraparenchymal fungal abscesses did not exhibit apparent restricted diffusion, with median rADC (range) of 2.8 (1.3\u20133.4) and 1.2 (1.1\u20131.8), respectively. With exclusion of hemorrhagic lesions, an rADC of 0.65 had a specificity\/sensitivity of 98%\/78% for intraparenchymal bacterial abscess. Apparent restricted diffusion on DWI and ADC is a useful marker for identifying intraparenchymal bacterial abscesses among ring\u2010enhancing lesions. However, extraparenchymal bacterial empyema and fungal abscesses may not exhibit this feature.<\/jats:p>","DOI":"10.1111\/vru.70085","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T07:25:56Z","timestamp":1758093956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diffusion\u2010Weighted Imaging of Intracranial Ring\u2010Enhancing Lesions"],"prefix":"10.1111","volume":"66","author":[{"given":"Adrien M.","family":"Dupanloup","sequence":"first","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig S.","family":"Brown","sequence":"additional","affiliation":[{"name":"Veterinary Medical Teaching Hospital School of Veterinary Medicine University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M.","family":"Vernau","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehren M.","family":"McLarty","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Dickinson","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.12809\/hkjr2117070"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2022.07.001"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.13098"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.13064"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.152.5.1073"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2019.00286"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.778320"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1995.tb00206.x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2011.01848.x"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01151"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.40-6-659"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v8.i9.785"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4736516"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.006"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-018-0624-3"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00027.2007"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13130420"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2014.04.012"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0b013e318278bee1"},{"key":"e_1_2_13_21_1","unstructured":"E. 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