{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:21:32Z","timestamp":1758846092327,"version":"3.44.0"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A 3\u2010year\u2010old Dalmatian was presented with anorexia, vomiting, and lethargy that progressed to neurological signs with a mixed hepatopathy. MRI identified bilaterally symmetric, ill\u2010defined hyperintensities in the thalamus, medial and lateral geniculate bodies, and red nuclei on T2\u2010weighted (T2W) and transverse T2W fluid\u2010attenuation inversion\u2010recovery (T2\u2010FLAIR) images, and bilaterally symmetric, ill\u2010defined T1\u2010hyperintensities in the lentiform nuclei and thalamus suggestive of an underlying metabolic dysfunction. Systemic workup revealed an underlying hepatopathy. A hepatic biopsy revealed severe copper\u2010associated hepatitis with a digital copper quantification of 3052\u00a0\u00b5g\/g dry weight. Clinical signs and MRI changes both improved following chelation therapy. The MRI findings and hepatic biopsy results led to a diagnosis of copper storage hepatopathy, consistent with Wilson's disease. This is the first description of brain MRI findings secondary to Wilson's disease in dogs.<\/jats:p>","DOI":"10.1111\/vru.70087","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:16:02Z","timestamp":1758795362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: MRI Diagnosis of Wilson's Disease in a 3\u2010Year\u2010Old Dalmatian"],"prefix":"10.1111","volume":"66","author":[{"given":"Natalie","family":"Durant","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5138-3802","authenticated-orcid":false,"given":"Matthew","family":"Paek","sequence":"additional","affiliation":[{"name":"VetRad Worthington Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9147-6079","authenticated-orcid":false,"given":"Wilfried","family":"Mai","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"issue":"12","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1007\/s00234-020-02511-y","article-title":"Bilateral Lesions of the Basal Ganglia and Thalami (Central Grey Matter)\u2010Pictorial Review","volume":"62","author":"Cauter S.","year":"2020","journal-title":"Neuroradiology"},{"issue":"29","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.4254\/wjh.v7.i29.2859","article-title":"Wilson's Disease: A Review of What We Have Learned","volume":"7","author":"Rodriguez\u2010Castro K. 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