{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:42:13Z","timestamp":1773013333407,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ventricular empyema is a rare but severe complication of central nervous system (CNS) infections in dogs, with a poor prognosis due to limited treatment options. A 6\u2010year\u2010old intact female Pomeranian (1.9\u00a0kg) presented with acute\u2010onset nonambulatory tetraparesis, spontaneous nystagmus, and head tilt. Hematological analysis revealed leukopenia with neutropenia and elevated C\u2010reactive protein (CRP), suggesting systemic inflammation. MRI showed ventricular dilation with distinct stratified fluid\u2013fluid levels. The dependent material was hypointense on T2\u2010weighted (T2W) images and unsuppressed on T2W FLAIR (fluid\u2010attenuated inversion recovery). It was hyperintense on diffusion\u2010weighted imaging (DWI) and hypointense on apparent diffusion coefficient (ADC) maps, consistent with restricted diffusion. Its position changed with repositioning, suggesting a gravity\u2010dependent nature. Cervical spinal cord MRI revealed a T2W hyperintense, contrast\u2010enhancing intramedullary lesion from C3 to C7. Cerebrospinal fluid (CSF) analysis confirmed severe neutrophilic pleocytosis with numerous bacilli, later identified as\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    . Despite antibiotic therapy, the patient's condition deteriorated, leading to euthanasia. No extracranial infectious source was identified, supporting hematogenous dissemination as the most plausible route of infection. This is the first reported case of\n                    <jats:italic>E. coli<\/jats:italic>\n                    \u2010induced ventricular empyema in veterinary medicine confirmed via advanced imaging. This report highlights the diagnostic role of DWI\/ADC mapping and the novel use of patient repositioning to assess intraventricular material dynamics, underscoring the need for further research into advanced imaging and treatment strategies.\n                  <\/jats:p>","DOI":"10.1111\/vru.70112","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:43:40Z","timestamp":1768297420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MRI Features of Ventricular Empyema Caused by\n                    <i>Escherichia coli<\/i>\n                    in a Dog"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5950-176X","authenticated-orcid":false,"given":"Jongwon","family":"Koo","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Imaging, College of Veterinary Medicine Konkuk University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jupill","family":"Chang","sequence":"additional","affiliation":[{"name":"SD Animal Medical Center  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minsu","family":"Lee","sequence":"additional","affiliation":[{"name":"SD Animal Medical Center  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaehwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Imaging, College of Veterinary Medicine Konkuk University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kidong","family":"Eom","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Imaging, College of Veterinary Medicine Konkuk University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1995.tb01089.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.2002.tb02348.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16605"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/vrc2.840"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12859"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.180.1.1800071"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X18792657"},{"key":"e_1_2_7_9_1","first-page":"515","article-title":"Pyogranulomatous Meningoencephalitis With Ventriculitis Due to Actinomyces spp. in a Dog","volume":"36","author":"Couto C. 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B.","year":"2001","journal-title":"AJNR American Journal of Neuroradiology"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/ajns.AJNS_45_18"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.06.057"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.46308\/kmj.2023.00080"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.184.4.01841101"}],"container-title":["Veterinary Radiology &amp; Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vru.70112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vru.70112","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vru.70112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:24:16Z","timestamp":1773008656000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vru.70112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/vru.70112"],"URL":"https:\/\/doi.org\/10.1111\/vru.70112","archive":["Portico"],"relation":{},"ISSN":["1058-8183","1740-8261"],"issn-type":[{"value":"1058-8183","type":"print"},{"value":"1740-8261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70112"}}