{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T02:36:48Z","timestamp":1785811008697,"version":"3.56.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Conventionally fractionated (CFRT) radiotherapy (20\u00a0\u00d7\u00a02.5\u00a0Gy) is commonly used in clinical practice for canine pituitary tumors (PTs), yet published data on long\u2010term outcomes and imaging response remain limited. Medical records were retrospectively reviewed for dogs diagnosed with PTs that received definitive\u2010intent radiation therapy (RT) with a planned total dose of 50\u00a0Gy in 20 fractions between 2014 and 2022. Prognostic factors, including age, sex, weight, the presence of neurological signs, pituitary\u2010dependent endocrine abnormalities, pituitary size and ratio to brain, and tumor response according to RECIST, were evaluated for association with outcome measures using Cox proportional hazard models. Twenty\u2010nine dogs were included in this multi\u2010institutional study. Follow\u2010up imaging was available for 14 dogs (48.2%); nine (64.3%) achieved partial response, and five (35.7%) had stable disease, including sustained tumor reduction exceeding 3 years in four dogs. Median progression\u2010free survival was 523 days (95% CI, 57\u20132469 days), and the median all\u2010cause survival time was 669 days (95% CI, 58\u20132469 days). Estimated 1\u2010, 2\u2010, and 3\u2010year survival rates were 65%, 48%, and 24%, respectively. Hyperadrenocorticism was significantly associated with reduced all\u2010cause survival (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.02). Three dogs were alive at the time of analysis. Acute Grade 1 brain toxicity occurred in four dogs. Hypoadrenocorticism developed in two dogs at 67 and 232 days after RT initiation. One dog developed a presumptive radiation\u2010induced trigeminal nerve sheath tumor 1724 days after RT, suspected to represent late toxicity. CFRT RT, delivered at 50\u00a0Gy in 2.5\u00a0Gy fractions, provides durable tumor control with few adverse events. Monitoring for post\u2010RT hypoadrenocorticism is warranted.\n                  <\/jats:p>","DOI":"10.1111\/vru.70141","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T04:20:55Z","timestamp":1769487655000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tolerability and Efficacy Following Definitive\u2010Intent Fractionated Radiotherapy for Canine Pituitary Tumors"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9930-7706","authenticated-orcid":false,"given":"Silvia","family":"Caeiro","sequence":"first","affiliation":[{"name":"The Royal (Dick) School of Veterinary Studies The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1174-5409","authenticated-orcid":false,"given":"Nicholas","family":"Goody","sequence":"additional","affiliation":[{"name":"The Royal (Dick) School of Veterinary Studies The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9142-4743","authenticated-orcid":false,"given":"Juan Carlos","family":"Serra","sequence":"additional","affiliation":[{"name":"The Royal (Dick) School of Veterinary Studies The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0170-3934","authenticated-orcid":false,"given":"Valerie J.","family":"Poirier","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Ontario Veterinary College University of Guelph  Guelph Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8315-1909","authenticated-orcid":false,"given":"Jessica","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine, University of California\u2010Davis  Davis California USA"},{"name":"Department of Radiation Oncology Medical School University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9051-6649","authenticated-orcid":false,"given":"Sumari","family":"Dancer","sequence":"additional","affiliation":[{"name":"The Royal (Dick) School of Veterinary Studies The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6407-4963","authenticated-orcid":false,"given":"Ian G.","family":"Handel","sequence":"additional","affiliation":[{"name":"The Royal (Dick) School of Veterinary Studies The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5588-4055","authenticated-orcid":false,"given":"Magdalena","family":"Parys","sequence":"additional","affiliation":[{"name":"The Royal (Dick) School of Veterinary Studies The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"33","article-title":"Canine Pituitary Macrotumors","volume":"30","author":"Moore S. 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