{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T15:18:16Z","timestamp":1788016696096,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Portal vein velocity (PVV) is a useful indirect indicator of portal pressure. Reference values for PVV have been previously established in healthy, non\u2010sedated dogs with reported ranges of 14.7\u00a0\u00b1\u00a02.5 and 18.1\u00a0\u00b1\u00a07.6\u00a0cm\/s. PVV may be influenced by physiological and pathological factors; for example, a correlation between body weight and PVV has been documented; however, the effect of other factors is unknown. The primary aims of this prospective comparative study were to investigate the effect of standardized intravenous sedation protocol of medetomidine (2\u20133\u00a0\u00b5g\/kg) and butorphanol (0.3\u00a0mg\/kg) on PVV and to determine whether post\u2010sedation PVV results would fall below the portal hypertension threshold of 10\u00a0cm\/s. Six triplex\u2010Doppler PVV measurements were obtained pre\u2010 and post\u2010sedation on 15 client\u2010owned dogs undergoing abdominal ultrasonography for conditions unrelated to primary liver disease. The mean PVV pre\u2010sedation was 14.9\u00a0\u00b1\u00a03.98\u00a0cm\/s and 3\u2010min post\u2010sedation was 10.4\u00a0\u00b1\u00a03.73\u00a0cm\/s, representing a statistically significant reduction in PVV (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). The mean PVV was below 10\u00a0cm\/s in 3\/15 (20%) dogs pre\u2010sedation and below 10\u00a0cm\/s in 9\/15 (60%) dogs post\u2010sedation. There was no effect of age, sex, or weight on PVV before and\/or after sedation. Sedation with medetomidine and butorphanol caused a significant reduction in PVV at 3\u2010min post\u2010administration. This finding should be considered when evaluating hepatic and portal hemodynamics in dogs, as 60% (9\/15) of the sedated cases with presumed normal hepatic function exhibited post\u2010sedation PVV at levels seen with portal hypertension.\n                  <\/jats:p>","DOI":"10.1111\/vru.70175","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:19:58Z","timestamp":1776687598000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of a Standardized Sedation Protocol on Portal Vein Velocity Measurements in Hospitalized Dogs Using Triplex\u2010Doppler Ultrasonography"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-7284","authenticated-orcid":false,"given":"Wiktoria","family":"Jamont","sequence":"first","affiliation":[{"name":"Section of Veterinary Clinical Sciences Department of Diagnostic Imaging School of Veterinary Medicine University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4904-9265","authenticated-orcid":false,"given":"Anne\u2010Lorraine","family":"Peschard","sequence":"additional","affiliation":[{"name":"Wear Referrals Veterinary Specialist and Emergency Hospital  Bradbury UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-3619","authenticated-orcid":false,"given":"Monica","family":"Augusto","sequence":"additional","affiliation":[{"name":"Section of Veterinary Clinical Sciences School of Veterinary Medicine University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4711-7567","authenticated-orcid":false,"given":"Cliona","family":"Skelly","sequence":"additional","affiliation":[{"name":"Section of Veterinary Clinical Sciences Department of Diagnostic Imaging School of Veterinary Medicine University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0193-4118","authenticated-orcid":false,"given":"Antonella","family":"Puggioni","sequence":"additional","affiliation":[{"name":"Section of Veterinary Clinical Sciences Department of Diagnostic Imaging School of Veterinary Medicine University College Dublin  Dublin 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