{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:28:19Z","timestamp":1787758099969,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study assessed the feasibility of contrast\u2010enhanced ultrasound (CEUS) for evaluating renal perfusion in horses and compared perfusion parameters between age groups. In a prospective study, eight healthy horses were divided into young (3\u20135 years,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a04) and old (16\u201317 years,\n                    <jats:italic>n\u00a0<\/jats:italic>\n                    =\u00a04) groups. All animals underwent B\u2010mode, Doppler ultrasonography, and CEUS of the right kidney after an intravenous bolus of SonoVue (0.02\u00a0mL\/kg). Qualitative analysis assessed contrast kinetics, whereas quantitative parameters (peak intensity, time to peak [TP], area under the curve, and wash\u2010out time) were obtained from time\u2013intensity curves in the renal cortex and medulla. The technique was safely performed in all horses, and the 0.02\u00a0mL\/kg dose proved optimal for achieving adequate renal enhancement and consistent quantitative measurements. Quantitative analysis revealed a significantly longer TP in the renal cortex of older horses compared to young ones (\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a00.03), suggesting an age\u2010related reduction in perfusion velocity. No other parameters showed significant differences. CEUS proved to be a feasible and safe method for assessing renal perfusion in horses. The prolonged cortical TP in older animals indicates that CEUS may be a sensitive tool for detecting early, subclinical perfusion changes associated with aging, warranting further investigation in horses with renal disease.\n                  <\/jats:p>","DOI":"10.1111\/vru.70188","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T10:17:17Z","timestamp":1780136237000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Renal Perfusion in Healthy Horses: A Feasibility Study With Contrast\u2010Enhanced Ultrasound"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3209-6767","authenticated-orcid":false,"given":"Diana Villa Verde","family":"Salazar","sequence":"first","affiliation":[{"name":"Departamento De Medicina Veterin\u00e1ria, Faculdade de Zootecnia e Engenharia De Alimentos Universidade De S\u00e3o Paulo \u2013 FZEA\/USP  Pirassununga S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia Alves","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento De Medicina Veterin\u00e1ria, Faculdade de Zootecnia e Engenharia De Alimentos Universidade De S\u00e3o Paulo \u2013 FZEA\/USP  Pirassununga S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Henrique Salles","family":"Brito","sequence":"additional","affiliation":[{"name":"Departamento De Medicina Veterin\u00e1ria, Faculdade de Zootecnia e Engenharia De Alimentos Universidade De S\u00e3o Paulo \u2013 FZEA\/USP  Pirassununga S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9760-8631","authenticated-orcid":false,"given":"Ricardo Andr\u00e9s Ramirez","family":"Uscategui","sequence":"additional","affiliation":[{"name":"HVUT, Facultad De Medicina Veterinaria y Zootecnia Universidad Del Tolima  Ibagu\u00e9 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Carolina Mazeto","family":"Ercolin","sequence":"additional","affiliation":[{"name":"Departamento De Medicina Veterin\u00e1ria, Faculdade de Zootecnia e Engenharia De Alimentos Universidade De S\u00e3o Paulo \u2013 FZEA\/USP  Pirassununga S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9699-7172","authenticated-orcid":false,"given":"Gabriela Castro Lopes","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Departamento De Medicina Veterin\u00e1ria, Faculdade de Zootecnia e Engenharia De Alimentos Universidade De S\u00e3o Paulo \u2013 FZEA\/USP  Pirassununga S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3229-9396","authenticated-orcid":false,"given":"Luiz Paulo Nogueira","family":"Aires","sequence":"additional","affiliation":[{"name":"Departamento De Cl\u00ednica e Cirurgia Veterin\u00e1ria, Faculdade de Ci\u00eancias Agr\u00e1rias e Veterin\u00e1rias Universidade Estadual Paulista \u201cJ\u00falio De Mesquita Filho\u201d \u2013 FCAV\/Unesp  Jaboticabal S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano Andrade","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento De Medicina Veterin\u00e1ria, Faculdade de Zootecnia e Engenharia De Alimentos Universidade De S\u00e3o Paulo \u2013 FZEA\/USP  Pirassununga S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus Ant\u00f4nio Rossi","family":"Feliciano","sequence":"additional","affiliation":[{"name":"Departamento De Medicina Veterin\u00e1ria, Faculdade de Zootecnia e Engenharia De Alimentos Universidade De S\u00e3o Paulo \u2013 FZEA\/USP  Pirassununga S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-44329-6.00016-4"},{"key":"e_1_2_10_3_1","volume-title":"Tratado de Fisiologia M\u00e9dica","author":"Hall J. 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