{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:59:27Z","timestamp":1790679567497,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Standardized uptake value maximum (SUVmax), metabolic tumor volumes (MTV), and total lesion glycolysis (TLG) are metabolic parameters used to quantify tumors detected on fluorine\u201018 fluorodeoxyglucose positron emission tomography\/computed tomography (18F\u2010FDG PET\/CT). This is a subset project from a larger pilot study where dogs diagnosed with lymphoma via lymph node aspirates were staged and monitored with serial 18F\u2010FDG PET\/CT before, during, and after completion of standard of care chemotherapy. The aim of this prospective study was to evaluate metabolic parameters within the spleen in dogs with naive lymphoma and establish cutoff values for these metabolic parameters to predict lymphoma dissemination to the spleen (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a07 dogs, 17 splenic samples). Splenic contours were performed at each time point to compare splenic cytology to splenic SUVmax, MTV, and TLG. Statistically significant receiver operating characteristic (ROC) curve\u2010derived cutoff values were found for SUVmax (cutoff\u00a0&gt;\u00a03.55,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u2264\u00a00.05) and MTV with a threshold of 1.5 SUV (cutoff\u00a0&gt;\u00a0325.7,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u2264\u00a00.05). Additionally, there are significantly higher mean\/median splenic SUV, MTV, and TLG among dogs with lymphoma in the spleen compared to those with benign splenic cytology. Therefore, certain cutoff values for SUVmax, MTV, and TLG may be able to predict splenic dissemination. These results may allow for noninvasive staging, monitoring of therapeutic response, and evaluation for recurrence of lymphoma following remission.\n                  <\/jats:p>","DOI":"10.1111\/vru.70241","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:28:39Z","timestamp":1790677719000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spleens With Disseminated Lymphoma Exhibit Higher Standardized Uptake Value Maximum, Metabolic Tumor Volumes, and Total Lesion Glycolysis on Fluorine\u201018 Fluorodeoxyglucose Positron Emission Tomography\/Computed Tomography"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9364-6577","authenticated-orcid":false,"given":"Jesse","family":"Johnson","sequence":"first","affiliation":[{"name":"Veterinary Diagnostic Imaging Department Environmental Health and Radiological Sciences Department Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0074-8233","authenticated-orcid":false,"given":"Lynn","family":"Griffin","sequence":"additional","affiliation":[{"name":"Advanced Animal Cancer Imaging LLC  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7832-4832","authenticated-orcid":false,"given":"Kathryn","family":"Vickery","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Flint Animal Cancer Center Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8521-2528","authenticated-orcid":false,"given":"Elissa","family":"Randall","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic Imaging Department Environmental Health and Radiological Sciences Department Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Withrow and MacEwen's Small Animal Clinical Oncology","author":"Vail D. 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