{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:09:48Z","timestamp":1790161788984,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Morphological variations or transposition of the ventral lamina of the sixth cervical vertebra (C6) are well documented in horses. Radiography remains the primary modality for identifying these osseous variations, whereas scintigraphy provides a functional assessment of bone activity; however, its diagnostic accuracy for this condition has not been established. This retrospective single\u2010center study evaluated the diagnostic performance of scintigraphy compared with radiography for detecting C6\/C7 ventral laminar anomalies and determined an optimal C6:C7 uptake ratio cutoff. Thirty\u2010four horses underwent both radiographic and scintigraphic examination. Radiography served as the reference standard, classifying horses as normal (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a022) or abnormal (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a012; unilateral\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a05, bilateral\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a07). Semiquantitative scintigraphic analysis was performed using a C6:C7 uptake ratio derived from background\u2010corrected counts per pixel. The visual scintigraphic assessment demonstrated 75.0% sensitivity (95% CI: 42.8%\u201394.5%) and 72.7% specificity (95% CI: 50.9%\u201388.7%). Semiquantitative receiver\u2010operating characteristic (ROC) analysis yielded an optimal C6:C7 ratio cutoff of 0.81 (area under the curve [AUC]\u00a0=\u00a00.762), providing 66.7% sensitivity and 81.8% specificity. The C6:C7 ratio was significantly higher in abnormal horses compared with normal horses for both the left (0.860\u00a0\u00b1\u00a00.149;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.006) and right (0.812\u00a0\u00b1\u00a00.148;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.035) sides. No significant differences within\u2010subject side\u2010to\u2010side (left\u2013right) C6:C7 ratio were detected. Scintigraphy demonstrated moderate diagnostic accuracy for detecting C6:C7 ventral laminar anomalies. A C6:C7 ratio threshold of 0.81 may serve as a practical adjunct screening parameter, though validation in larger populations is warranted.\n                  <\/jats:p>","DOI":"10.1111\/vru.70243","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:20:31Z","timestamp":1789543231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Accuracy of Scintigraphy for Detecting Morphological Variation of the Sixth Cervical Vertebral Ventral Lamina in Horses: A Retrospective Study"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2686-0407","authenticated-orcid":false,"given":"Mahmoud","family":"Mageed","sequence":"first","affiliation":[{"name":"Equipixel Veterinary Teleradiology  Bakum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahlaa","family":"Dyab","sequence":"additional","affiliation":[{"name":"Equipixel Veterinary Teleradiology  Bakum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Przewo\u017any","sequence":"additional","affiliation":[{"name":"Equi Vet Serwis Sp. z o.o.  Buk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani16030424"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani10040667"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2022.104054"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12397"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12393"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.21836\/PEM20210606"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.18435\/vamp29368"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.13140"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.105756"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.24.04.0230"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani13142384"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2015.03.002"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/eve.70062"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.14127"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12350"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/eve.13810"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12917"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2013.08.003"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/39.4.561"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.309.6947.102"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.13229"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3769\/radioisotopes.26.6_371"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani16030482"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_2_12_26_1","volume-title":"Quantitative Assessment for Whole Body Bone Scan Images Using Imagej Software","author":"Mohammedkhair A. Z. B.","year":"2017"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12695"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani14121830"}],"container-title":["Veterinary Radiology &amp; Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vru.70243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vru.70243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vru.70243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:19:52Z","timestamp":1790158792000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vru.70243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/vru.70243"],"URL":"https:\/\/doi.org\/10.1111\/vru.70243","archive":["Portico"],"relation":{},"ISSN":["1058-8183","1740-8261"],"issn-type":[{"value":"1058-8183","type":"print"},{"value":"1740-8261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70243"}}