{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:10:10Z","timestamp":1790161810825,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Radiology Ultrasound"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The incidence of non\u2010irradiation\u2010related complications in cats receiving radiotherapy has not been previously reported. Medical records of 167 cats treated with radiotherapy under general anesthesia at a single institution (2002\u20132025) were reviewed. Head\/neck tumors were most common (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0119). Ninety\u2010two cats (55%) received short\u2010course radiotherapy (1\u20138 fractions, median 4), and 75 cats (45%) received longer course radiotherapy (10\u201319 fractions, median 16). Median treatment duration spanned 16 calendar days (range, 1\u201335). Complications resolving without intervention or requiring outpatient treatment were categorized as mild, and those requiring hospitalization for supportive care or discontinuation of radiation therapy (RT) were considered severe. Mild anesthesia\u2010related complications occurred in 72 cats (43%), whereas mild non\u2010anesthesia\u2010related complications occurred in 30 cats (18%). Three cats (2%) experienced treatment delays due to mild complications. Preexisting hypertensive chronic kidney disease (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0201) and vasopressor use (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0001) were associated with mild anesthesia\u2010related complications on multivariate analysis. Severe complications requiring hospitalization occurred in 19 cats (11%), including gastrointestinal, fever, anemia, neurologic, renal, cardiac, endocrine, and ocular events; treatment was delayed in 7 (4%) and discontinued in 12 (7%) of these cats. Weight loss from the start to end of treatment (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.016) was associated with severe complications on multivariate analysis, with 40% of cats losing &gt;5% of body weight during treatment. As the hematocrit decreased by &gt;5% in 27% of cats, recheck after RT is recommended. Six cats (4%) were euthanized during radiotherapy due to tumor progression (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a03) or severe complications (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a03). Overall, 11% of cats experienced severe non\u2010irradiation\u2010related complications that rarely led to death.\n                  <\/jats:p>","DOI":"10.1111\/vru.70255","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:15:59Z","timestamp":1790154959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non\u2010Irradiation\u2010Related Complications in Cats Undergoing Radiation Therapy: A Single\u2010Institution Retrospective Study of 167 Cats (2002\u20132025)"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5577-8042","authenticated-orcid":false,"given":"Skylar R.","family":"Sylvester","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Cornell University Hospital for Animals  Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4889-4560","authenticated-orcid":false,"given":"Tracy L.","family":"Gieger","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Cornell University Hospital for Animals  Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"issue":"3","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/vco.12454","article-title":"Owner Perceptions of Radiotherapy Treatment for Veterinary Patients With Cancer","volume":"17","author":"Smith P. A. D.","year":"2019","journal-title":"Veterinary and Comparative Oncology"},{"issue":"3","key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2460\/javma.253.3.307","article-title":"Retrospective Survey of Owners' Experiences With Palliative Radiation Therapy for Pets","volume":"253","author":"Fan V. C.","year":"2018","journal-title":"Journal of the American Veterinary Medical Association"},{"issue":"5","key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jsap.12972","article-title":"Owners' Perception of Their Dogs' Quality of Life During and After Radiotherapy for Cancer","volume":"60","author":"Serras A. R.","year":"2019","journal-title":"Journal of Small Animal Practice"},{"issue":"5","key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.cvsm.2019.05.001","article-title":"Update in Veterinary Radiation Oncology: Focus on Stereotactic Radiation Therapy","volume":"49","author":"Nolan M. W.","year":"2019","journal-title":"Veterinary Clinics of North America Small Animal Practice"},{"issue":"6","key":"e_1_2_13_6_1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/vru.12671","article-title":"A Survey of Stereotactic Radiation Therapy in Veterinary Medicine","volume":"59","author":"Dunfield E. M.","year":"2018","journal-title":"Veterinary Radiology & Ultrasound: The Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association"},{"issue":"1","key":"e_1_2_13_7_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/vru.12556","article-title":"Retrospective Analysis of Nonradiation Complications in Dogs Undergoing Radiation Therapy","volume":"59","author":"Farrelly J.","year":"2018","journal-title":"Veterinary Radiology & Ultrasound: The Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association"},{"issue":"5","key":"e_1_2_13_8_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1740-8261.2001.tb00973.x","article-title":"Toxicity Criteria of the Veterinary Radiation Therapy Oncology Group","volume":"42","author":"LaDue T.","year":"2001","journal-title":"Veterinary Radiology & Ultrasound: The Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association"},{"issue":"10","key":"e_1_2_13_9_1","doi-asserted-by":"crossref","DOI":"10.1177\/1098612X241285269","article-title":"Perioperative Anaesthetic Complications in Healthy Cats Undergoing Anaesthesia for Neutering in First Opinion Practice","volume":"26","author":"Brown J. F.","year":"2024","journal-title":"Journal of Feline Medicine and Surgery"},{"issue":"1","key":"e_1_2_13_10_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.5326\/15473317-35-1-13","article-title":"Complications and Mortality Associated With Anesthesia in Dogs and Cats","volume":"35","author":"Gaynor J. S.","year":"1999","journal-title":"Journal of the American Animal Hospital Association"},{"issue":"9","key":"e_1_2_13_11_1","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.2460\/javma.231.9.1347","article-title":"Clinical Assessment of Repeated Propofol\u2010Associated Anesthesia in Cats","volume":"231","author":"Bley C. R.","year":"2007","journal-title":"Journal of the American Veterinary Medical Association"},{"issue":"2","key":"e_1_2_13_12_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.vaa.2022.11.010","article-title":"Comparison of Alfaxalone and Propofol on Haematological and Serum Biochemical Variables in Cats Undergoing Radiotherapy With Sevoflurane Maintenance","volume":"50","author":"K\u00f6rner M.","year":"2023","journal-title":"Veterinary Anaesthesia and Analgesia"},{"issue":"5","key":"e_1_2_13_13_1","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1111\/jvim.15867","article-title":"Risk Factors Associated With Progressive Increases in Serum Creatinine Concentrations in Cats With Cancer Receiving Doxorubicin","volume":"34","author":"Kopecny L.","year":"2020","journal-title":"Journal of Veterinary Internal Medicine"}],"container-title":["Veterinary Radiology &amp; Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vru.70255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vru.70255","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vru.70255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:20:32Z","timestamp":1790158832000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vru.70255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/vru.70255"],"URL":"https:\/\/doi.org\/10.1111\/vru.70255","archive":["Portico"],"relation":{},"ISSN":["1058-8183","1740-8261"],"issn-type":[{"value":"1058-8183","type":"print"},{"value":"1740-8261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2025-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70255"}}