{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:56:47Z","timestamp":1792180607172,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T00:00:00Z","timestamp":1435536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To estimate the prevalence and risk factors for a diagnosis of cranial cruciate ligament (CCL) disease in dogs and to describe the management of such cases attending primary\u2010care veterinary practices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Historical cohort with a nested case\u2013control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Sample population<\/jats:title>\n                    <jats:p>Nine hundred and fifty\u2010three dogs diagnosed with CCL disease from 171,522 dogs attending 97 primary\u2010care practices in England.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records of dogs attending practices participating in the VetCompass project that met selection criteria were assessed. Univariate and multivariate logistic regression methods were used to evaluate association of possible risk factors with diagnosis of CCL disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of CCL disease diagnosis was estimated at 0.56% (95% confidence interval 0.52\u20130.59). Compared with crossbred dogs, Rottweilers, West Highland White Terriers, Golden Retrievers, Yorkshire Terriers, and Staffordshire Bull Terriers showed increased odds of CCL disease diagnosis while Cocker Spaniels showed reduced odds. Increasing bodyweight within breeds was associated with increased odds of diagnosis. Dogs aged over 3 years had increased odds of diagnosis compared with dogs aged less than 3 years. Neutered females had 2.1 times the odds of diagnosis compared with entire females. Insured dogs had 4 times the odds of diagnosis compared with uninsured dogs. Two\u2010thirds of cases were managed surgically, with insured and heavier dogs more frequently undergoing surgery. Overall, 21% of cases were referred, with referral more frequent in heavier and insured dogs. Referred dogs more frequently had surgery and an osteotomy procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Breed predispositions and demographic factors associated with diagnosis and case management of CCL disease in dogs identified in this study can be used to help direct future research and management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vsu.12349","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T02:43:52Z","timestamp":1435545832000},"page":"777-783","source":"Crossref","is-referenced-by-count":85,"title":["Epidemiology of Cranial Cruciate Ligament Disease Diagnosis in Dogs Attending Primary\u2010Care Veterinary Practices in England"],"prefix":"10.1111","volume":"44","author":[{"given":"Frances E.","family":"Taylor\u2010Brown","sequence":"first","affiliation":[{"name":"The Royal Veterinary College Hatfield Hertfordshire United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Meeson","sequence":"additional","affiliation":[{"name":"The Royal Veterinary College Hatfield Hertfordshire United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave C.","family":"Brodbelt","sequence":"additional","affiliation":[{"name":"The Royal Veterinary College Hatfield Hertfordshire United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Church","sequence":"additional","affiliation":[{"name":"The Royal Veterinary College Hatfield Hertfordshire United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"McGreevy","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science The University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Thomson","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science The University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan G.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"The Royal Veterinary College Hatfield Hertfordshire United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1055\/s-0038-1633097","article-title":"Incidence of canine appendicular musculoskeletal disorders in 16 veterinary teaching hospitals from 1980 through 1989","volume":"7","author":"Johnson JA","year":"1994","journal-title":"Vet Comp Orthop Traumatol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3415\/VCOT-10-04-0055"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5326\/0400385"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.12.1818"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2011.01202.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2011.01073.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"811","DOI":"10.2460\/javma.1999.215.06.811","article-title":"Breed, sex, and body weight as risk factors for rupture of the cranial cruciate ligament in young dogs","volume":"215","author":"Duval JM","year":"1999","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.2460\/javma.1993.203.07.1016","article-title":"Epidemiology of cranial cruciate ligament rupture in dogs","volume":"203","author":"Whitehair JG","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2009.00532.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000146469.08655.e2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1988.tb02286.x"},{"key":"e_1_2_7_13_1","first-page":"193","article-title":"Canine cranial cruciate ligament rupture in profile: 2002\u20132007","volume":"49","author":"Harasen G","year":"2008","journal-title":"Can Vet J"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1977.tb05825.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2010.01.007"},{"key":"e_1_2_7_16_1","volume-title":"Independent inquiry into dog breeding","author":"Bateson P","year":"2010"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1017\/S0962728600031821","article-title":"Breeding for quality of life","volume":"16","author":"McGreevy PD","year":"2010","journal-title":"Anim Welfare"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.0695.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2010.00974.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0147-51-42"},{"key":"e_1_2_7_21_1","unstructured":"VetCompass VetCompass: Health surveillance for UK companion animals. RVC Electronic Media Unit. London2013"},{"key":"e_1_2_7_22_1","unstructured":"Medivet. Medivet: the veterinary partnership.2014;http:\/\/www.medivet.co.uk\/. Accessed January 14 2014"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.333.7557.39"},{"key":"e_1_2_7_24_1","unstructured":"The VeNom Coding Group VeNom Veterinary Nomenclature. Ed T. V. C. Group. VeNom Coding Group2013"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.101133"},{"key":"e_1_2_7_26_1","unstructured":"Epi Info 7 CDC. Atlanta Georgia Centers for Disease Control and Prevention 2012"},{"key":"e_1_2_7_27_1","unstructured":"Haahr M: RANDOM.ORG: True random number service. In:http:\/\/www.random.org\/. TSDA2012"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jhered\/esg004"},{"key":"e_1_2_7_29_1","volume-title":"Essential medical statistics","author":"Kirkwood BR","year":"2003"},{"key":"e_1_2_7_30_1","volume-title":"Veterinary epidemiologic research","author":"Dohoo I","year":"2009"},{"key":"e_1_2_7_31_1","unstructured":"RothmanKJ GreenlandS.Measures of disease frequency in Rothman KJ Greenland S (eds):Modern epidemiology(ed 2). Lippincott\u2010Raven Publishers199829\u201346"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471722146"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(03)00177-X"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2009.11.005"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2010.00654.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.2460\/ajvr.1985.46.09.1842","article-title":"Correlative biomechanical and histologic study of the cranial cruciate ligament in dogs","volume":"46","author":"Vasseur PB","year":"1985","journal-title":"Am J Vet Res"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1984.tb00801.x"},{"key":"e_1_2_7_38_1","volume-title":"Repair of the ruptured cruciate ligament in the dog","author":"Strande A","year":"1967"},{"key":"e_1_2_7_39_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1055\/s-0037-1617478","article-title":"Excision arthroplasty of the hip joint in dogs and cats. Clinical, radiographic, and gait analysis findings from the Department of Surgery, Veterinary Faculty of the Ludwig\u2010Maximilians\u2010University of Munich, Germany","volume":"23","author":"Off W","year":"1997","journal-title":"Vet Comp Orthop Traumatol"},{"key":"e_1_2_7_40_1","first-page":"1133","article-title":"Surgical correction of rupture of the anterior cruciate ligament in the dog","volume":"150","author":"Hohn RB","year":"1967","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.226.232"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2012.01052.x"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2005.00016.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2009.00628.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-6356"},{"key":"e_1_2_7_46_1","first-page":"1","article-title":"Prevalence of disorders recorded in dogs attending primary\u2010care veterinary practices in England","volume":"9","author":"O'Neill DG","year":"2014","journal-title":"PLoS One"}],"container-title":["Veterinary Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvsu.12349","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vsu.12349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T18:23:44Z","timestamp":1748456624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vsu.12349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,29]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/vsu.12349"],"URL":"https:\/\/doi.org\/10.1111\/vsu.12349","archive":["Portico"],"relation":{},"ISSN":["0161-3499","1532-950X"],"issn-type":[{"value":"0161-3499","type":"print"},{"value":"1532-950X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,29]]}}}