{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:33:56Z","timestamp":1790134436131,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T00:00:00Z","timestamp":1458777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the properties of a ZipFix<jats:sup>\u00ae<\/jats:sup>(ZipFix) implant in equine laryngeal cartilages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Ex vivo biomechanical study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample Population<\/jats:title><jats:p>Equine arytenoid (n=36) and cricoid cartilages (n=18).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Suture bites were placed in arytenoid or cricoid cartilages using a ZipFix<jats:sup>\u00ae<\/jats:sup>implant or a single strand of USP 5 braided polyester (TiCron\u2122), and arytenoid and cricoid cartilages were separately subjected to single load to failure (25 N preload) or cyclic loading for 1,000 cycles, followed by single load to failure. Load, distraction, and stiffness were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four arytenoid\u2010ZipFix cartilages fractured on implant placement. Under single load, arytenoid\u2010ZipFix (n=9) failed at a greater mean load (359.01\u2009\u00b1\u200957.98 N) than arytenoid\u2010Ticron (159.11\u2009\u00b1\u200922.98 N; n=12;<jats:italic>P<\/jats:italic>&lt;.001). Arytenoid\u2010ZipFix stiffness (31.32\u2009\u00b1\u20094.26 N\/mm) was significantly greater than arytenoid\u2010Ticron (13.18\u2009\u00b1\u20092.60 N\/mm;<jats:italic>P<\/jats:italic>&lt;.001). Cricoid\u2010ZipFix stiffness (20.83\u2009\u00b1\u20093.37 N\/mm) was significantly greater than cricoid\u2010Ticron (13.6\u2009\u00b1\u20093.82 N\/mm; n=6;<jats:italic>P<\/jats:italic>=.006). Under cyclic load, arytenoid\u2010ZipFix distraction (2.53\u2009\u00b1\u20090.63 mm; n=5) was significantly less than arytenoid\u2010Ticron (5.06\u2009\u00b1\u20091.37 mm; n=6,<jats:italic>P<\/jats:italic>=.006). After cyclic load, arytenoid\u2010ZipFix failure load (295.16\u2009\u00b1\u200954.95 N) was significantly greater than arytenoid\u2010Ticron (127.69\u2009\u00b1\u200932.67 N;<jats:italic>P<\/jats:italic>=.002). Arytenoid\u2010ZipFix stiffness (35.59\u2009\u00b1\u20091.58 N\/mm) was significantly greater than arytenoid\u2010Ticron (24.10\u2009\u00b1\u20096.85 N\/mm;<jats:italic>P<\/jats:italic>=.019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In arytenoid cartilages, the sternal ZipFix<jats:sup>\u00ae<\/jats:sup>implant was significantly stronger and stiffer compared to a single strand of Ticron. During placement of the ZipFix<jats:sup>\u00ae<\/jats:sup>implant, frequent arytenoid cartilage failure occurred before testing, suggesting the implant is not suitable for clinical application.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.12466","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T05:32:59Z","timestamp":1458797579000},"page":"450-455","source":"Crossref","is-referenced-by-count":6,"title":["Ex Vivo Mechanical Evaluation of a Sternal ZipFix<sup>\u00ae<\/sup>Implant for Prosthetic Laryngoplasty in Horses"],"prefix":"10.1111","volume":"45","author":[{"given":"Harry J.","family":"Markwell","sequence":"first","affiliation":[{"name":"Department of Large Animal Medicine, College of Veterinary Medicine University of Georgia Athens Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. O. 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