{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:12:24Z","timestamp":1784286744701,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T00:00:00Z","timestamp":1473120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Intramural award from the College of Veterinary Medicine, The Ohio State University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess technical feasibility and mechanical properties of 3 locking plate designs (Zero\u2010P, Zero\u2010P VA, and Uniplate 2) for use in the canine cervical spine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective ex vivo study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Cadaver cervical spines from skeletally mature large breed dogs (n\u2009=\u200918).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Specimens were screened using radiography and allocated into balanced groups based on bone density. Stiffness of intact C4\u2013C5 vertebral motion units was measured in extension, flexion, and lateral bending using nondestructive 4\u2010point bend testing. Uniplate 2 was then implanted at C4\u2013C5 and mechanical testing was repeated. Mechanical test data were compared against those from 6 spines implanted with monocortical screws, an allograft ring spacer, and PMMA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Zero\u2010P and Zero\u2010P VA systems could not be surgically implanted due to anatomical constraints in the vertebral column sizes of the canine cervical spines used in this study. Fixation with Uniplate 2 or with screws\/PMMA significantly increased stiffness of the C4\u2013C5 vertebral motion units compared to unaltered specimens (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) in extension. Stiffness of the titanium screw\/PMMA fixation was significantly greater than the Uniplate 2 construct in extension. Flexion and lateral bending could not be evaluated in 3 of 6 specimens in the Uniplate 2 group due to failure at the bone\/implant interface during extension testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fixation with Uniplate 2 was biomechanically inferior to screws\/PMMA. Particularly concerning was the incidence of vertebral fracture after several testing cycles. Based on our results, Zero\u2010P, Zero\u2010P VA, and Uniplate 2 cannot be recommended for use in dogs requiring cervical fusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.12536","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T14:12:39Z","timestamp":1473171159000},"page":"901-908","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of Three Human Cervical Fusion Implants for Use in the Canine Cervical Vertebral Column"],"prefix":"10.1111","volume":"45","author":[{"given":"Emily J.","family":"Morrison","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine, Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S.","family":"Litsky","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics College of Medicine, Ohio State University Columbus Ohio"},{"name":"Department of Biomedical Engineering College of Engineering, Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey T.","family":"Fosgate","sequence":"additional","affiliation":[{"name":"Department of Production Animal Studies Faculty of Veterinary Science, University of Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca F.","family":"Hettlich","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine, Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2009.00541.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1998.tb03617.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2001.tb06032.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7234-3209-8.50015-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1632969"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1989.tb01070.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2460\/javma.1996.208.01.61","article-title":"Modified distraction\u2010stabilization techniques using an interbody polymethyl methacrylate plug in dogs with caudal cervical spondylomyelopathy","volume":"208","author":"Dixon B","year":"1996","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12325"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2011.00850.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2008.00400.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2013.12044.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2013.12040.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2010.00755.x"},{"key":"e_1_2_7_15_1","first-page":"1","article-title":"Zero profile anterior cervical interbody fusion (ACIF) device","author":"DePuy Synthes Spine: Zero\u2010P and Zero\u2010P chronOS","year":"2008","journal-title":"Synthes Technique Guide"},{"key":"e_1_2_7_16_1","first-page":"1","article-title":"Zero\u2010P VA Variable angle zero\u2010profile anterior cervical interbody fusion (ACIF) device","author":"DePuy Synthes Spine","year":"2013","journal-title":"Synthes Technique Guide"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-012-2446-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000000864"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2013.03.032"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCO.0b013e3280964dda"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2014.12165.x"},{"key":"e_1_2_7_22_1","unstructured":"LinPS: United States Patent Application Publication: Uniplate Cervical device2004;1\u20136.http:\/\/www.google.com\/patents\/US20040236333"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2011.07.003"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2011.01.027"},{"key":"e_1_2_7_25_1","first-page":"1490","article-title":"Uniplate with the Orion anterior cervical plate fixation biomechanics single gap study","volume":"16","author":"Zhang F","year":"2008","journal-title":"Chin J Orthop Surg"},{"key":"e_1_2_7_26_1","first-page":"488","article-title":"Comparison between single\u2010screw and triangulated, double\u2010screw fixation in anterior spine surgery: a biomechanical test","volume":"18","author":"Ogon M","year":"2003","journal-title":"J OrthopTrauma"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3415\/VCOT-12-05-0061"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-3774-0_2"},{"key":"e_1_2_7_29_1","first-page":"477","volume-title":"AO principles of fracture management in the dog and cat","author":"Richards RG","year":"2005"},{"key":"e_1_2_7_30_1","first-page":"236","volume-title":"): AO principles of fracture management in the dog and cat","author":"Toombs JP","year":"2005"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2014.12095.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2015.05.034"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e3182254ea3"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csefa.2015.03.004"}],"container-title":["Veterinary Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvsu.12536","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvsu.12536","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vsu.12536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T06:46:32Z","timestamp":1718779592000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vsu.12536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,6]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/vsu.12536"],"URL":"https:\/\/doi.org\/10.1111\/vsu.12536","archive":["Portico"],"relation":{},"ISSN":["0161-3499","1532-950X"],"issn-type":[{"value":"0161-3499","type":"print"},{"value":"1532-950X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,6]]}}}