{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:27:32Z","timestamp":1788866852117,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T00:00:00Z","timestamp":1494028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To document the outcome of dogs with appendicular primary bone tumors treated with stereotactic radiotherapy (SRT) and concurrent stabilization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Multi\u2010institutional retrospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Eighteen dogs with presumptive or definitive diagnosis of appendicular osteosarcoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of dogs with appendicular primary bone tumors treated with SRT and stabilization were reviewed for signalment, preoperative staging and diagnostics, radiation dose, stabilization method, and outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The distal radius was affected in 13\/18 cases. Osteosarcoma or sarcoma was confirmed cytologically or histologically in 15\/18 cases. Seven dogs were diagnosed with a pathological fracture at the time of treatment, and 11 were considered at high risk for pathological fracture. Dogs received a single dose (n\u2009=\u20095) or 3 doses (n\u2009=\u200913) of SRT. Surgical stabilization was performed under the same anesthetic event as the final dose of SRT in 10 dogs. Stabilization was achieved with a bone plate (n\u2009=\u200915) or interlocking nail (n\u2009=\u20093). Seventeen dogs received adjuvant chemotherapy. Complications occurred in 16\/17 dogs, 15\/17 of those being considered major complications. Four dogs experienced more than one complication. Infection was the most common complication, diagnosed in 15\/17 cases, and considered as a major complication in 13\/15 cases. Postoperative fracture was recorded as a major complication in 3 cases. Nine dogs were amputated at a median of 152 days. The median survival time was 344 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment of bone tumors with SRT and concurrent stabilization was associated with a prohibitively high complication rate in dogs. Alternative methods for limb salvage should be considered for dogs at risk for pathologic fracture.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.12669","type":"journal-article","created":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T10:42:44Z","timestamp":1494067364000},"page":"829-837","source":"Crossref","is-referenced-by-count":30,"title":["Outcome and complications in dogs with appendicular primary bone tumors treated with stereotactic radiotherapy and concurrent surgical stabilization"],"prefix":"10.1111","volume":"46","author":[{"given":"Sarah E.","family":"Boston","sequence":"first","affiliation":[{"name":"Small Animal Clinical Sciences, University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arathi","family":"Vinayak","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics &amp; Children's Oncology Group, University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Larue","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Bacon","sequence":"additional","affiliation":[{"name":"Fitzpatrick Referrals Eashing Godalming United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2987-7722","authenticated-orcid":false,"given":"Jason A.","family":"Bleedorn","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, University of Wisconsin Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos H. 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