{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T17:36:51Z","timestamp":1774546611325,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of arthroscopic lavage and repeated intra\u2010articular administration of antibiotic in adult horses and foals with septic arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Retrospective clinical study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Adult horses and foals with septic arthritis (n\u2009=\u200962).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Age, sex, cause of septic synovitis, joint involved, hospitalization time, and outcome were recorded. Arthroscopic lavage was performed at day 0 (D 0). Synovial fluid was collected every 48 hours prior to intra\u2010articular administration of antibiotic, and until hospital discharge. Synovial nucleated cell count, total protein, and percentage of neutrophils were compared across time and between subjects with a favorable or unfavorable outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Synovial nucleated cell counts decreased progressively and were lower at all times compared to D 0. Percentages of neutrophils were lower than baseline at D 8 and 10, only. Total protein contents decreased progressively and were lower than baseline at D 2, 4, 6, 8, 10, and 14. When adult horses and foals with a favorable outcome were compared to those with an unfavorable outcome, the nucleated cell count was lower at D 10, 12, and 14 and the percentage of neutrophils was lower at D 4 only, but total protein content did not differ between groups at any time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Synovial nucleated cell counts and total protein concentrations decreased after arthroscopic lavage and repeated intra\u2010articular administration of antibiotic in horses and foals with septic arthritis. Synovial nucleated cell count is limited as a monitoring tool during treatment of septic arthritis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.12696","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T20:15:36Z","timestamp":1501791336000},"page":"1008-1016","source":"Crossref","is-referenced-by-count":27,"title":["Effect of arthroscopic lavage and repeated intra\u2010articular administrations of antibiotic in adult horses and foals with septic arthritis"],"prefix":"10.1111","volume":"46","author":[{"given":"Matthieu","family":"Cousty","sequence":"first","affiliation":[{"name":"Centre Hospitalier V\u00e9t\u00e9rinaire Equin de Livet Cour Samson, St Michel de Livet France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"David Stack","sequence":"additional","affiliation":[{"name":"UCD, University College Dublin Campus Belfield Dublin 4 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