{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T19:20:21Z","timestamp":1782588021136,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Resident Research and Research in Animal Health Grant Programs, Cornell University"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate long\u2010term loading patterns using subchondral bone density (SBD) distribution of the tibial plateau after tibial plateau leveling osteotomy (TPLO) and tibial tuberosity advancement (TTA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Adult (&gt; 2 years), medium to large breed dogs (&gt;20 kg) that had been treated with TPLO or TTA at least 1 year prior to the study were recruited. A normal cohort of similar age and weight dogs with normal physical and orthopedic examinations served as control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dogs were sedated for computed tomography (CT) of the stifle, and DICOM (digital imaging and communications in medicine) files were processed for CT osteoabsorptiometry (CTOAM). Tibial plateaus were sampled at 6 zones, and CTOAM was used to determine regional and maximal areas of SBD as a marker of joint loading.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were collected on 48 stifles in 31 dogs (15 TPLO, 11 TTA, 22 control). Lower Hounsfield unit (HU) values were measured in the caudal and mid\u2010region of the lateral tibial plateau after TPLO and compared to normal. HU values did not differ between joints treated with TTA and those in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TPLO may alter stifle load distribution relative to the normal control group. There were no differences between TTA and the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance\/Impact<\/jats:title><jats:p>Despite ongoing osteoarthritis (OA) in dogs after surgical intervention for cranial cruciate disease, changes in tibial SBD are minor and may not correlate with clinical function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.12790","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T06:05:53Z","timestamp":1522649153000},"page":"566-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010term effects of tibial plateau leveling osteotomy and tibial tuberosity advancement on tibial plateau subchondral bone density in dogs"],"prefix":"10.1111","volume":"47","author":[{"given":"Elizabeth S.","family":"Leach","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Cornell University Ithaca New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1189-8664","authenticated-orcid":false,"given":"Ursula","family":"Krotscheck","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Cornell University Ithaca New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey J.","family":"Goode","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Cornell University Ithaca New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1365-3284","authenticated-orcid":false,"given":"Galina M.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Cornell University Ithaca New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"B\u00f6ttcher","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleine Haustiere, Freie Universit\u00e4t Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.147.12.325"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.1604"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2007.00250.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.2460\/javma.1983.183.04.456","article-title":"Cranial tibial thrust: a primary force in the canine stifle","volume":"183","author":"Slocum B","year":"1983","journal-title":"J Am Vet Med Assoc."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(93)50082-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2008.00439.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12445"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2008.00470.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2008.00471.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.72.3.410"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2012.00973.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1623760"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.08.003"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650071409"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2000.61.1252"},{"key":"e_1_2_7_17_1","first-page":"655","article-title":"Change in subchondral mineralization after reconstruction of the anterior cruciate ligament of the sheep","volume":"97","author":"Anetzberger H","year":"1994","journal-title":"Unfallchirurg."},{"key":"e_1_2_7_18_1","unstructured":"KrausD.Luxatio patellae congenita medialis und Ruptur des Ligamentum cruciatum craniale beim Hund\u2014eine CT\u2010osteoabsorptiometrische Studie[doctoral dissertation]. Munich Germany: Faculty of Veterinary Medicine Ludwig Maximilian University of Munich;2006."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2002.63.1159"},{"key":"e_1_2_7_20_1","article-title":"Subchondral bone density distribution of the talus in clinically normal Labrador retrievers","volume":"15","author":"Dingemanse W","year":"2016","journal-title":"BMC Vet Res."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339307"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2008.0297"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2014.12121.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2010.00674.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-72019-2"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.72.4.491"},{"key":"e_1_2_7_27_1","volume-title":"The Visualization Toolkit. An Object\u2010Oriented Approach to 3D Graphics","author":"Schroeder W","year":"2006"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-012-2297-7"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2010.00655.x"},{"key":"e_1_2_7_30_1","article-title":"In vivo fluoroscopic stifle kinematics before and after tibial tuberosity advancement","volume":"44","author":"Schwede M","year":"2015","journal-title":"Vet Surg."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2009.00628.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/jvet.2003.50051"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2010.00669.x"}],"container-title":["Veterinary Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvsu.12790","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vsu.12790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T09:48:52Z","timestamp":1751536132000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vsu.12790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/vsu.12790"],"URL":"https:\/\/doi.org\/10.1111\/vsu.12790","archive":["Portico"],"relation":{},"ISSN":["0161-3499","1532-950X"],"issn-type":[{"value":"0161-3499","type":"print"},{"value":"1532-950X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"2017-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}