{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T09:51:36Z","timestamp":1786787496874,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T00:00:00Z","timestamp":1532563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Olive's Way Oncology Fund"},{"name":"The Rumba Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To define and compare clinical characteristics of canine primary appendicular hemangiosarcoma (HSA) and telangiectatic osteosarcoma (tOSA), including signalment, presentation, response to treatment, and prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Multi\u2010institutional retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Seventy dogs with primary appendicular HSA or tOSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patient data were obtained from institutions' medical records. Immunohistochemistry was applied to archived tissues to establish tumor type. Patient characteristics, treatment responses, and outcomes were described and compared by tumor type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010one HSA and 29 tOSA were identified. Dogs with HSA were more likely than dogs with tOSA to be male and have hind limb tumors; 78% of HSA occurred in hind limbs, particularly the tibia. Dogs with tOSA weighed a median of 9.9\u2009kg (95% CI 4.6\u201015.3) more than dogs with HSA. Most dogs received antineoplastic treatment, predominantly amputation with or without adjuvant chemotherapy. Overall survival with local treatment and chemotherapy was 299 days (95% CI 123\u2010750) for HSA and 213 days (95% CI 77\u2010310) for tOSA. Younger age and more aggressive treatment were associated with longer survival in dogs with HSA but not tOSA. One\u2010year survival rates did not differ between dogs with HSA (28%) and those with tOSA (7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Distinct clinical features were identified between HSA and tOSA in this population. Both tumors were aggressive, with a high incidence of pulmonary metastases. However, local treatment combined with chemotherapy led to an average survival 7 months for tOSA and 10 months for HSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance<\/jats:title><jats:p>HSA should be considered as a differential in dogs with aggressive lytic bone lesions, particularly medium\u2010sized dogs with tibial lesions. HSA has a unique clinical presentation but similar therapeutic response and outcome to OSA. Amputation and chemotherapy appear to prolong survival in some dogs with HSA and tOSA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.12926","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T06:08:42Z","timestamp":1532671722000},"page":"774-783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Primary appendicular hemangiosarcoma and telangiectatic osteosarcoma in 70 dogs: A<scp>V<\/scp>eterinary<scp>S<\/scp>ociety of<scp>S<\/scp>urgical<scp>O<\/scp>ncology retrospective study"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-2653","authenticated-orcid":false,"given":"Michelle A.","family":"Giuffrida","sequence":"first","affiliation":[{"name":"Department of Surgical and Radiological Sciences University of California\u2010Davis Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra A.","family":"Kamstock","sequence":"additional","affiliation":[{"name":"Kampath Diagnostics and Investigation Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6695-6273","authenticated-orcid":false,"given":"Laura E.","family":"Selmic","sequence":"additional","affiliation":[{"name":"The Flint Animal Cancer Center, Department of Clinical Sciences Colorado State University Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Pass","sequence":"additional","affiliation":[{"name":"The Flint Animal Cancer Center, Department of Clinical Sciences Colorado State University Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Szivek","sequence":"additional","affiliation":[{"name":"Small Animal Clinical Sciences University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Mison","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies School of Veterinary Medicine, University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Boston","sequence":"additional","affiliation":[{"name":"Small Animal Clinical Sciences University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie E.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Iowa State University Ames Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Robat","sequence":"additional","affiliation":[{"name":"University of Wisconsin Veterinary Medical Teaching Hospital Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4554-8013","authenticated-orcid":false,"given":"Janet A.","family":"Grimes","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Auburn University College of Veterinary Medicine, Auburn University Auburn Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl C.","family":"Maritato","sequence":"additional","affiliation":[{"name":"MedVet Medical and Cancer Centers for Pets Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Bacon","sequence":"additional","affiliation":[{"name":"Fitzpatrick Referrals Oncology and Soft Tissue Ltd Surrey United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,26]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"54","article-title":"Canine osteosarcoma. 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