{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:00:15Z","timestamp":1793325615730,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report perioperative characteristics, complications, histopathologic diagnosis and outcome in cats undergoing surgical treatment for primary hyperparathyroidism (PHPT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Multi\u2010institutional, retrospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Thirty\u2010two client\u2010owned cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of cats treated with surgical removal of 1 or more parathyroid gland(s) with confirmed histopathologic evaluation were reviewed. Cats were divided into preoperative ionized calcium (iCa) groups corresponding to the 33rd, 67th, and 100th percentiles of the preoperative iCa results of the study population. Follow\u2010up consisted of phone conversation with owners or primary veterinarian.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ionized calcium was above reference range in all cats (median 1.8\u2009mmol\/L [interquartile range, 1.5\u20131.9]). Abnormal tissue was excised after cervical exploration in all cats. The most common histopathologic diagnoses were parathyroid adenoma in 20 of 32 (62.5%) cats and parathyroid carcinoma in 7 of 32 (21.9%) cats. At discharge, 6 of 32 (18.8%) cats had hypercalcemia, 5 of 32 (15.6%) had hypocalcemia, and 21 of 32 (65.6%) were normocalcemic. Preoperative iCa did not correlate with postoperative iCa. The median follow\u2010up time was 332\u2009days (range, 7\u20133156). Overall median survival time was 1109\u2009days (95% CI, 856\u20131332). Survival time was not associated with preoperative iCa group, hypocalcemia at discharge, hypercalcemia at discharge, or diagnosis of carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this cohort of cats, parathyroid adenoma was the most common cause of PHPT, and surgical treatment resulted in very good median survival time. Preoperative iCa was not predictive of postoperative hypocalcemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance<\/jats:title><jats:p>Surgical parathyroidectomy for treatment of PHPT in cats provides a favorable prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.13165","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T09:42:37Z","timestamp":1548150157000},"page":"367-374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Perioperative characteristics, histological diagnosis, and outcome in cats undergoing surgical treatment of primary hyperparathyroidism"],"prefix":"10.1111","volume":"48","author":[{"given":"Ameet","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Clinical Studies Ontario Veterinary College, University of Guelph Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-2653","authenticated-orcid":false,"given":"Michelle A.","family":"Giuffrida","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine, University of California\u2010Davis Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B.","family":"Thomson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Minnesota St Paul Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Baum","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Ontario Veterinary College, University of Guelph Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Kramek","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Minnesota St Paul Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius M.","family":"Liptak","sequence":"additional","affiliation":[{"name":"Department of Surgery VCA Canada\u2013Alta Vista Animal Hospital Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Hyndman","sequence":"additional","affiliation":[{"name":"Department of Surgery Veterinary Emergency Clinic Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendon","family":"Ringwood","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Minnesota St Paul Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Smeak","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Colorado State University Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Ham","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Tufts University North Grafton Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley","family":"Thieman\u2010Mankin","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences Texas A&amp;M University College Station Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shauna L.","family":"Blois","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Ontario Veterinary College, University of Guelph Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Boston","sequence":"additional","affiliation":[{"name":"VCA Canada\u2013404 Veterinary Emergency and Referral Newmarket Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2005.tb00268.x"},{"key":"e_1_2_6_3_1","first-page":"694","article-title":"Primary hyperparathyroidism in a dog","volume":"168","author":"Legendre AM","year":"1976","journal-title":"J Am Vet Med Assoc."},{"key":"e_1_2_6_4_1","first-page":"1471","article-title":"Primary hyperparathyroidism in a dog: biochemical, bone histomorphometric, and pathologic findings","volume":"189","author":"Weir EC","year":"1986","journal-title":"J Am Vet Med Assoc."},{"key":"e_1_2_6_5_1","first-page":"942","article-title":"Primary hyperparathyroidism in a dog","volume":"164","author":"Wilson JW","year":"1974","journal-title":"J Am Vet Med 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