{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T02:36:48Z","timestamp":1785811008292,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the morbidity and mortality associated with adrenalectomy with cavotomy for resection of invasive adrenal neoplasms in dogs and evaluate risk factors for perioperative outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Forty\u2010five client\u2010owned dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dogs that underwent open adrenalectomy with cavotomy for resection of adrenal masses with tumor thrombus extending into the vena cava were included. Clinicopathologic data were harvested from medical records. Selected clinical, imaging, and operative variables were statistically evaluated as risk factors for packed red blood cell transfusion, nephrectomy, perioperative death, and overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six of 45 masses were pheochromocytomas, 7 were adrenocortical carcinomas, and 2 were unknown type. Caval thrombus terminated prehepatically in 21 of 45 dogs and extended beyond the porta hepatis but terminated prediaphragmatically (intrahepatic prediaphragmatic location) in 15 dogs and thrombi extended postdiaphragmatically in 5 dogs. Thirty\u2010four (76%) dogs were discharged from the hospital, and 11 (24%) dogs died or were euthanized prior to discharge. Median overall survival time for all 45 dogs was 547\u2009days (95%CI 146\u2013710). Bodyweight, tumor type, and size and extent of caval thrombus did not affect survival to discharge, but postdiaphragmatic (rather than prediaphragmatic) thrombus termination was associated with a greater risk of death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Long\u2010term survival was common in dogs that survived the perioperative period. Postdiaphragmatic thrombus extension affected the prognosis for overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance<\/jats:title><jats:p>Findings of this study help to stratify operative risk in dogs with adrenal neoplasia and caval invasion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.13221","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T01:11:50Z","timestamp":1556673110000},"page":"742-750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Perioperative morbidity and mortality in dogs with invasive adrenal neoplasms treated by adrenalectomy and cavotomy"],"prefix":"10.1111","volume":"48","author":[{"given":"Philipp D.","family":"Mayhew","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine University of California\u2010Davis  Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Boston","sequence":"additional","affiliation":[{"name":"VCA Canada, 404 Veterinary Emergency and Referral Hospital  Newmarket, Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison L.","family":"Zwingenberger","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine University of California\u2010Davis  Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-2653","authenticated-orcid":false,"given":"Michelle A.","family":"Giuffrida","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine University of California\u2010Davis  Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Runge","sequence":"additional","affiliation":[{"name":"Matthew J. Ryan Veterinary Hospital at the University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Holt","sequence":"additional","affiliation":[{"name":"Matthew J. Ryan Veterinary Hospital at the University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S.","family":"Raleigh","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine University of California\u2010Davis  Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameet","family":"Singh","sequence":"additional","affiliation":[{"name":"Departments of Clinical Studies Ontario Veterinary College, University of Guelph  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6132-156X","authenticated-orcid":false,"given":"William T. N.","family":"Culp","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine University of California\u2010Davis  Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Brad","family":"Case","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine University of Florida  Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0852-0644","authenticated-orcid":false,"given":"Michele A.","family":"Steffey","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine University of California\u2010Davis  Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid M.","family":"Balsa","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine University of California\u2010Davis  Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1997.tb00464.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-37-1-93"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.223.654"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0182.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.1.77"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2009.01593.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5669"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.239.2.216"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.242.12.1715"},{"key":"e_1_2_6_11_1","first-page":"2281","volume-title":"Veterinary Surgery Small Animal","author":"Adin CA","year":"2018"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1994.tb03222.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2001.111996"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(97)00329-9"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198909000-00014"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12728"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.101691"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12592"}],"container-title":["Veterinary Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vsu.13221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vsu.13221","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vsu.13221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T13:13:27Z","timestamp":1694351607000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vsu.13221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,29]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/vsu.13221"],"URL":"https:\/\/doi.org\/10.1111\/vsu.13221","archive":["Portico"],"relation":{},"ISSN":["0161-3499","1532-950X"],"issn-type":[{"value":"0161-3499","type":"print"},{"value":"1532-950X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,29]]},"assertion":[{"value":"2018-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}