{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:04:04Z","timestamp":1785449044917,"version":"3.56.0"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009961","name":"American College of Veterinary Surgeons Foundation","doi-asserted-by":"publisher","award":["Surgeon\u2010in\u2010Training Grant"],"award-info":[{"award-number":["Surgeon\u2010in\u2010Training Grant"]}],"id":[{"id":"10.13039\/100009961","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the influence of short\u2010term administration of carprofen on bone healing in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Randomized controlled experimental study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Eighteen purpose\u2010bred sexually mature hound dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Tibial osteotomies were performed, and dogs were divided into three groups: no carprofen (n = 6), 2\u2010week administration of carprofen at 2.2\u2009mg\/kg twice daily (n = 6), and 8\u2010week administration of carprofen at 2.2\u2009mg\/kg twice daily (n = 5). Bone healing was evaluated radiographically at 4 and 8\u2009weeks postoperatively. Postmortem, fracture healing was assessed via biomechanical testing (three\u2010point bending), histological cartilage:callus ratio, and bone mineral density (BMD) with quantitative computed tomography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No biomechanical difference was detected between dogs that received no carprofen and those that received 2\u2009weeks of carprofen or between those that received 2\u2009weeks vs 8\u2009weeks of carprofen. Stiffness (<jats:italic>P<\/jats:italic> =\u2009.035) and maximum stress (<jats:italic>P<\/jats:italic> =\u2009.042) were higher in dogs that received no carprofen than in those that received 8\u2009weeks of carprofen. Radiographic healing did not differ between dogs without carprofen and those with 2\u2010week administration of carprofen (<jats:italic>P<\/jats:italic> =\u2009.9923). However, tibias of dogs without carprofen and those with 2\u2010week administration of carprofen were more healed compared with those in the 8\u2010week\u2010carprofen group at 4 and 8\u2009weeks after surgery (<jats:italic>P<\/jats:italic> =\u2009.0011). No treatment effect was detected by cartilage:callus ratio or BMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Long\u2010term administration of carprofen had a negative effect on bone healing compared with short\u2010term or no administration of carprofen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance<\/jats:title><jats:p>Nonsteroidal anti\u2010inflammatory drugs should be used cautiously in dogs at risk for delayed bone healing, and administration should be discontinued beyond the perioperative period in dogs with fractures or osteotomies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.13282","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T14:19:41Z","timestamp":1562768381000},"page":"1318-1329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of short\u2010 and long\u2010term administration of nonsteroidal anti\u2010inflammatory drugs on osteotomy healing in dogs"],"prefix":"10.1111","volume":"48","author":[{"given":"Hayley M.","family":"Gallaher","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine Mississippi State University  Mississippi State Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine Mississippi State University  Mississippi State Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Wills","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Medicine, College of Veterinary Medicine Mississippi State University  Mississippi State Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren 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