{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:03:07Z","timestamp":1788307387091,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01 OD019911"],"award-info":[{"award-number":["K01 OD019911"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prognostic value of (1) colonic venous lactate or peripheral lactate values obtained before and after manual correction of a large colon volvulus and (2) a combination of variables including pelvic flexure biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Prospective clinical study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Forty adult horses in which large colon volvulus was diagnosed intraoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Colonic venous, peripheral venous, and arterial blood samples were collected to measure lactate values before and after manual correction. Mucosal biopsy samples were obtained in cases that underwent enterotomy or colonic resection and anastomosis. Interstitium to crypt (I:C) ratio and hemorrhage scores were measured. Optimal cutoff values were determined by receiver operator curve analysis, and associations between variables and short\u2010term outcome were determined by univariable regression. Short\u2010term survival was defined as horses being discharged from the hospital.<jats:italic>P<\/jats:italic>\u2009\u2264\u2009.05 was considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No association was found between colonic venous lactate values before (<jats:italic>P<\/jats:italic>= .011) or after (<jats:italic>P<\/jats:italic>= .201) manual correction of large colon volvulus and determination of short\u2010term outcome. Peripheral venous lactate at admission \u22653.2\u2009mmol\/L and after manual correction \u22655\u2009mmol\/L, arterial lactate postmanual correction \u22653.53\u2009mmol\/L, and histomorphometric measurements of mucosal hemorrhage \u22653 and I:C ratio\u2009&gt;\u20091 were associated with poor short\u2010term outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Peripheral lactate values, histomorphometric measures of I:C ratio, and hemorrhage score provided prognostic information that could help guide recommendations made to owners.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance<\/jats:title><jats:p>Peripheral lactate values after manual correction provide important intraoperative diagnostic information to assist in predicting case outcome in the operative and immediately postoperative period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.13361","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T12:02:15Z","timestamp":1578571335000},"page":"472-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prognostic value of colonic and peripheral venous lactate measurements in horses with large colon volvulus"],"prefix":"10.1111","volume":"49","author":[{"given":"Kindra. E.","family":"Orr","sequence":"first","affiliation":[{"name":"Peterson and Smith Equine Hospital Ocala Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. True","family":"Baker","sequence":"additional","affiliation":[{"name":"Hagyard Equine Medical Institute Lexington Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim M.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Peterson and Smith Equine Hospital Ocala Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faith E.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Peterson and Smith Equine Hospital Ocala Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol K.","family":"Clark","sequence":"additional","affiliation":[{"name":"Peterson and Smith Equine Hospital Ocala Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Donnie E.","family":"Slone","sequence":"additional","affiliation":[{"name":"Peterson and Smith Equine Hospital Ocala Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Callie A.","family":"Fogle","sequence":"additional","affiliation":[{"name":"North Carolina State University, College of Veterinary Medicine Raleigh North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3972-2812","authenticated-orcid":false,"given":"Liara M.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"North Carolina State University, College of Veterinary Medicine Raleigh North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516408X293529"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2008.00449.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0739(17)30243-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2012.00994.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2012.01081.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2007.00305.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2012.00620.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/jvet.2000.17836"},{"key":"e_1_2_7_10_1","first-page":"254","article-title":"Large colon volvulus: surgical treatment of 204 horses (1986\u20131995)","volume":"42","author":"Embertson RM","year":"1996","journal-title":"Proc Am Assoc Equine Pract."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12358"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1989.tb02689.x"},{"key":"e_1_2_7_13_1","first-page":"280","article-title":"Intravenous fluorescein dye as an indicator of small and large intestinal viability in the horse","volume":"2","author":"Sullins KE","year":"1986","journal-title":"Proc Equine Colic Res Symp."},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.2460\/javma.1994.204.11.1786","article-title":"Surface oximetry for intraoperative assessment of colonic viability in horses","volume":"204","author":"Snyder JR","year":"1994","journal-title":"J Am Vet Med Assoc."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1996.tb01389.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2006.00157.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12202"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12273"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2003.12.004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2014.12195.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1976.tb03289.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1534-6935.2003.00102.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2746\/0425164054529319"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2011.00859.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13147"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1746-7"},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.2460\/ajvr.1995.56.12.1642","article-title":"Abnormalities in oxygenation, coagulation, and fibrinolysis in colonic blood of horses with experimentally\u2010induced strangulation obstruction","volume":"56","author":"Kawcak CE","year":"1995","journal-title":"Am J Vet Res."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1998.tb00108.x"},{"key":"e_1_2_7_29_1","first-page":"801","article-title":"Morphologic alterations observed during experimental ischemia of the equine large colon","volume":"49","author":"Snyder JR","year":"1988","journal-title":"Am J Vet Res."},{"key":"e_1_2_7_30_1","first-page":"627","article-title":"Receiver operating characteristic (ROC) curve analysis for medical diagnostic test evaluation","volume":"4","author":"Hajian\u2010Tilaki K","year":"2013","journal-title":"Caspian J Intern Med."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14670"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.2746\/0425164054529328"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.240.10.1208"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0419.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/eve.12033"},{"key":"e_1_2_7_36_1","first-page":"316","article-title":"Pulmonary gas exchange and plasma lactate in horses with gastrointestinal disease undergoing emergency exploratory laparotomy: a comparison with an elective surgery horse population","volume":"41","author":"McCoy AM","year":"2012","journal-title":"Vet Surg."}],"container-title":["Veterinary Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvsu.13361","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vsu.13361","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vsu.13361","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vsu.13361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T22:34:21Z","timestamp":1722292461000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vsu.13361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,9]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/vsu.13361"],"URL":"https:\/\/doi.org\/10.1111\/vsu.13361","archive":["Portico"],"relation":{},"ISSN":["0161-3499","1532-950X"],"issn-type":[{"value":"0161-3499","type":"print"},{"value":"1532-950X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,9]]},"assertion":[{"value":"2019-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}