{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:50:12Z","timestamp":1762098612644,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe perioperative antimicrobial use in horses undergoing elective arthroscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design.<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample population.<\/jats:title><jats:p>Horses that underwent elective arthroscopy at one institution between July 2016 and May 2018, excluding those with a suspected infectious orthopedic disease or with a comorbidity that may have impacted prophylactic antimicrobial use decisions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records were reviewed to evaluate preoperative, intraoperative, and postoperative antimicrobial drug selection, dose, and timing. Associations between body weight and underdosing were evaluated by using analysis of variance, \u03c7<jats:sup>2<\/jats:sup>test was used for categorical comparisons, and least squares fit was used to evaluate factors associated with duration of postoperative antimicrobials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 150 horses, 149 (99.3%) received systemic preoperative antimicrobials. Only 53 (40.2%) horses were administered doses within 60\u2009minutes of surgical incision. First incision was performed more than two half\u2010lives after administration of sodium penicillin in 46 of 131 (35.1%) horses but in only 1 of 106 (0.8%) horses that received trimethoprim\u2010sulfadoxine. Body weight was associated with underdosing for penicillin (<jats:italic>P<\/jats:italic>\u2009=\u2009.0075) and trimethoprim\u2010sulfadoxine (<jats:italic>P<\/jats:italic>\u2009=\u2009.002) but not gentamicin (<jats:italic>P<\/jats:italic>\u2009=\u2009.92). Twenty\u2010six (17%) horses received one postoperative antimicrobial dose, while antimicrobials were continued in hospital for a mean of 22.3\u2009\u00b1\u20094.4\u2009hours after surgery in the other 123 horses. Among the 149 discharged horses, 115 (77.2%) were prescribed antimicrobials after discharge (range, 3\u201010\u2009days; median, 3\u2009days, interquartile range, 0\u2009days).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Deviations from common recommendations were apparent and provide evidence for the requirement to develop interventions to optimize perioperative prophylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance<\/jats:title><jats:p>Perioperative antimicrobial use practices should be regularly assessed to provide a benchmark and identify areas for intervention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.13382","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T09:50:14Z","timestamp":1579254614000},"page":"427-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Retrospective assessment of perioperative antimicrobial use for elective arthroscopy in horses"],"prefix":"10.1111","volume":"49","author":[{"given":"Noah","family":"Muntwyler","sequence":"first","affiliation":[{"name":"Ontario Veterinary College University of Guelph Guelph Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Soleil","family":"Dubois","sequence":"additional","affiliation":[{"name":"Ontario Veterinary College University of Guelph Guelph Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1896-1937","authenticated-orcid":false,"given":"J. 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