{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:31:35Z","timestamp":1791829895733,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T00:00:00Z","timestamp":1587600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Die Gesellschaft zur F\u00f6rderung Kynologischer Forschung e.V."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effect of perioperative pregabalin on pain behavior in dogs after intervertebral disc surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Prospective, randomized, controlled clinical trial with a blinded observer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Forty\u2010six client\u2010owned dogs undergoing intervertebral disc surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dogs were randomly assigned to two groups, with the placebo group receiving opioids alone and the pregabalin group receiving opioids plus pregabalin. Opioid analgesia consisted of 0.6\u2009mg\/kg\u2009l\u2010methadone given intravenously at anesthetic induction, followed by 0.2\u2009mg\/kg given at 8, 16, and 24\u2009hours after extubation and fentanyl patches applied at the end of surgery. Pregabalin was given orally (4\u2009mg\/kg) 1\u2009hour before anesthesia, followed by postoperative treatment three times per day (4\u2009mg\/kg) for 5\u2009days. The outcome measures were the treatment\u2010group differences in peri\u2010incisional mechanical sensitivity and Glasgow Composite Measure Pain Scale (CMPS\u2010SF) assessed during the first 5 postoperative days. Pregabalin serum concentrations were measured after 24, 72, and 120\u2009hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pregabalin reduced pain levels in the treatment group by a mean of 2.5 CMPS\u2010SF units (95% confidence interval [CI] = \u22123.19 to \u22121.83,<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) compared with the control group during the study period. Pregabalin increased the mechanical nociceptive threshold by a mean of 6.89\u2009N per day (95% CI = 1.87\u201011.92,<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and of 7.52\u2009N per day (95% CI = 2.29\u201012.77,<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) during the study period, depending on location. Mean levels of serum pregabalin were 5.1, 4.71, and 3.68\u2009\u03bcg\/mL at 24, 72, and 120\u2009hours postoperatively, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Postoperative signs of pain after surgical treatment of intervertebral disc herniation (IVDH) were reduced when dogs received perioperative pregabalin rather than opioids alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance<\/jats:title><jats:p>Perioperative pregabalin reduces postoperative pain after surgical treatment of IVDH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.13411","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T05:28:27Z","timestamp":1587706107000},"page":"905-913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Randomized controlled trial of pregabalin for analgesia after surgical treatment of intervertebral disc disease in dogs"],"prefix":"10.1111","volume":"49","author":[{"given":"Philipp A.","family":"Schmierer","sequence":"first","affiliation":[{"name":"Clinic for Small Animal Surgery, Vetsuisse Faculty University of Zurich Zurich Switzerland"},{"name":"Tierklinik Posthausen Posthausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"T\u00fcnsmeyer","sequence":"additional","affiliation":[{"name":"Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Tipold","sequence":"additional","affiliation":[{"name":"Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Hartnack\u2010Wilhelm","sequence":"additional","affiliation":[{"name":"Department for Biostatistics Vetsuisse Faculty University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Lesczuk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg Erlangen Germany"},{"name":"Department of Neurodegeneration Diagnostics Medical University of Bialystok Bialystok Poland"},{"name":"Department of Biochemical Diagnostics University Hospital of Bialystok Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine B. 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