{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:12:16Z","timestamp":1787508736036,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate histopathological features of synovium from dogs with cranial cruciate ligament disease (CCLD) to seek mechanisms of osteoarthritis (OA) associated with CCLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Retrospective, single\u2010institution case series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirty client\u2010owned dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Synovial biopsies (n\u00a0=\u00a030) obtained from stifles with CCLD were assessed by using two synovitis histopathology grading systems (Krenn and Hospital for Special Surgery [HSS]). The Krenn synovitis score was interpreted as \u201cno synovitis,\u201d \u201clow\u2010grade,\u201d or \u201chigh\u2010grade,\u201d while inflammatory subtype (low, mixed, or high) was determined by a computational algorithm within the HSS system. Comparison of synovitis scores was based on degree of CCL rupture and presence of meniscal tears.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Histopathological changes and synovitis scores were similar regardless of degree of rupture (partial n\u00a0=\u00a05, complete n\u00a0=\u00a025) or presence of meniscal injury (n\u00a0=\u00a012) and were characterized by hyperplastic and lymphoplasmacytic synovitis with increased vascularity (30\/30) and the presence of hemosiderin deposits (28\/30), binucleated plasma cells (28\/30), mucoid change (25\/30), and Mott cells (16\/30). Thirteen (43%) specimens were consistent with high\u2010grade synovitis according to the Krenn system, while 11 (37%) specimens fit into the high\u2010inflammatory subtype with the HSS system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Synovitis associated with canine CCLD in this study population was lymphoplasmacytic and was often highly inflammatory, with the presence of cells pertaining to humoral immunity. Humoral immune responses may play key roles in the synovitis associated with CCLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical significance<\/jats:title>\n                    <jats:p>Modulation of biological factors that provoke humoral immune responses may mitigate symptoms of OA that persist and progress even after surgical treatment of CCLD in dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vsu.13600","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T08:31:30Z","timestamp":1616747490000},"page":"1032-1041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Histologic evidence for a humoral immune response in synovitis associated with cranial cruciate ligament disease in dogs"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6255-1121","authenticated-orcid":false,"given":"Keiichi","family":"Kuroki","sequence":"first","affiliation":[{"name":"Thompson Laboratory for Regenerative Orthopaedics University of Missouri  Columbia Missouri USA"},{"name":"Department of Veterinary Pathobiology, Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine University of Missouri  Columbia, Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ned","family":"Williams","sequence":"additional","affiliation":[{"name":"Eastern Carolina Veterinary Referral  Wilmington, North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Cook","sequence":"additional","affiliation":[{"name":"Thompson Laboratory for Regenerative Orthopaedics University of Missouri  Columbia Missouri USA"},{"name":"Missouri Orthopaedic Institute University of Missouri  Columbia, Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.1604"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2010.00653.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2004.04024.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.230.11.1674"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34453"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/boneres.2016.44"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1229-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.02.012"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2007.04.006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.01.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.06.007"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874312901105010100"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.63.17"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00859.x"},{"key":"e_1_2_8_16_1","volume-title":"Robbins and Cotran Pathologic Basis of Disease","author":"Kumar V","year":"2015"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22446"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2017.12.006"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.47.4.300"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2543"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.74.3.386"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.71.7.750"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1078\/0344-0338-5710261"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02508.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40428"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.04.017"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1297361"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.32.4.387"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.235.4.386"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.80.2.152"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2003.09.007"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2017.07.004"},{"issue":"31","key":"e_1_2_8_33_1","first-page":"289","article-title":"Histopathological evaluation of canine stifle joint synovial membrane collected at the time of repair of cranial cruciate ligament rupture","volume":"995","author":"Galloway RH","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097329"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3337"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-015-0664-5"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.151068"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.12.007"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.08.027"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X12467868"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117685"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002960050029"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-234864"},{"key":"e_1_2_8_44_1","first-page":"1166","article-title":"Synovial membrane changes after experimental transection of the cranial cruciate ligament in dogs","volume":"46","author":"Lipowitz AJ","year":"1995","journal-title":"Am J Vet Res."},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280515"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330913"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.04.019"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025331"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2006.10.002"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.08.015"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2000.61.1456"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.2007.00977.x"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2009.139"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1003"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2005.01.005"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2013.03.006"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/26.1.5"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-694356"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066092"}],"container-title":["Veterinary Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vsu.13600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vsu.13600","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vsu.13600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T14:06:52Z","timestamp":1693318012000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vsu.13600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,26]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/vsu.13600"],"URL":"https:\/\/doi.org\/10.1111\/vsu.13600","archive":["Portico"],"relation":{},"ISSN":["0161-3499","1532-950X"],"issn-type":[{"value":"0161-3499","type":"print"},{"value":"1532-950X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,26]]},"assertion":[{"value":"2020-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}