{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:07:36Z","timestamp":1793275656111,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report data related to the short\u2010 and long\u2010term survival of dogs undergoing adrenalectomy for pheochromocytoma, and to determine the influence of preoperative alpha\u2010blocker therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Fifty\u2010three dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records were reviewed for dogs diagnosed with pheochromocytoma and treated with adrenalectomy between 2010 and 2020. Preoperative management, imaging studies, intraoperative cardiovascular instability, complications, and procedural information were recorded. When applicable, duration of survival and cause of death, time to recurrence or metastasis, and postoperative complications were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During anesthesia, a hypertensive episode was documented in 46\/53 dogs and arrhythmias were recorded in 16\/53 dogs. Of these, 37\/46 hypertensive dogs and 11\/16 dogs with arrhythmias were treated with an alpha\u2010blocker before surgery. Intraoperative systolic blood pressures reached higher levels by a magnitude of nearly 20% in dogs that were treated preoperatively with an alpha\u2010blocker (<jats:italic>P<\/jats:italic>\u00a0=\u2009.01). All dogs survived surgery and 44 survived to discharge. Follow up ranged from 6 to 1653\u2009days (median 450\u2009days). Median survival time for dogs discharged from the hospital was 1169\u2009days (3.2\u2009years). Recurrence and metastasis were suspected in 3 and 8 dogs, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Most dogs survived the immediate postoperative period and achieved long\u2010term survival with a low reported incidence of tumor recurrence or metastasis. Preoperative alpha\u2010blocker therapy was not associated with increased survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance<\/jats:title><jats:p>The favorable outcomes reported in this study should be taken into consideration when discussing treatment options for dogs with pheochromocytomas. This study provides no evidence to support preoperative alpha\u2010blocker therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.13771","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T07:14:29Z","timestamp":1644477269000},"page":"438-446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Short\u2010 and long\u2010term survival after adrenalectomy in 53 dogs with pheochromocytomas with or without alpha\u2010blocker therapy"],"prefix":"10.1111","volume":"51","author":[{"given":"Dory","family":"Enright","sequence":"first","affiliation":[{"name":"Department of Small Animal Veterinary Clinical Sciences Texas A&amp;M University College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanna M.","family":"Dickerson","sequence":"additional","affiliation":[{"name":"Department of Small Animal Veterinary Clinical Sciences Texas A&amp;M University College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet A.","family":"Grimes","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery College of Veterinary Medicine, University of Georgia Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Townsend","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery College of Veterinary Medicine, North Carolina State University Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley M.","family":"Thieman Mankin","sequence":"additional","affiliation":[{"name":"Department of Small Animal Veterinary Clinical Sciences Texas A&amp;M University College Station Texas 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