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High\u2010speed exercise history data were evaluated. Microdamage was assessed in fracture, fracture\u2010contralateral limb (FXCL) and control PSBs using whole bone lead uranyl acetate (LUA) staining with micro\u2010CT imaging or basic fuchsin histological analysis. Fracture toughness mechanical testing was carried out in 3\u2010point\u2010bending of microbeams created from PSB flexor cortices. Data were analyzed using ordinal logistic and linear regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Microdamage was detected most commonly in the articular subchondral region of PSBs via LUA micro\u2010CT and basic fuchsin histology. There were no differences in microdamage between FXCL and control PSBs. Fracture toughness values were similar for FXCL (1.31\u2009MPa\u221am) and control (1.35\u2009MPa\u221am) PSBs. Exercise histories were similar except that horses sustaining fracture spent a greater percentage of their careers in rest weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Microdamage was detected in the articular region of PSBs but was not greater in horses sustaining catastrophic PSB fracture. Fracture toughness of PSB flexor cortices did not differ between FXCL and control PSBs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance<\/jats:title><jats:p>Although uncommon, microdamage is localized to the articular region of Thoroughbred racehorse PSBs. Catastrophic PSB failure is not associated with lower PSB flexor cortex fracture toughness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.13816","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T04:50:47Z","timestamp":1654663847000},"page":"952-962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Proximal sesamoid bone microdamage is localized to articular subchondral regions in Thoroughbred racehorses, with similar fracture toughness between fracture and controls"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1767-3837","authenticated-orcid":false,"given":"Lauren K.","family":"Luedke","sequence":"first","affiliation":[{"name":"Cornell University College of Veterinary Medicine Department of Clinical Sciences Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe","family":"Ilevbare","sequence":"additional","affiliation":[{"name":"Cornell University College of Veterinary Medicine Department of Clinical Sciences Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kira J.","family":"Noordwijk","sequence":"additional","affiliation":[{"name":"Cornell University College of Veterinary Medicine Department of Clinical Sciences Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo M.","family":"Palomino","sequence":"additional","affiliation":[{"name":"Cornell University College of Engineering Department of Biomedical Engineering Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"McDonough","sequence":"additional","affiliation":[{"name":"Cornell University College of Veterinary Medicine Department of Biomedical Sciences Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott E.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Cornell University College of Veterinary Medicine Department of Population Medicine and Diagnostic Sciences Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1573-1549","authenticated-orcid":false,"given":"Parminder S.","family":"Basran","sequence":"additional","affiliation":[{"name":"Cornell University College of Veterinary Medicine Department of Clinical Sciences Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Cornell University College of Engineering Department of Materials Science and Engineering Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8534-8839","authenticated-orcid":false,"given":"Heidi L.","family":"Reesink","sequence":"additional","affiliation":[{"name":"Cornell University College of Veterinary Medicine Department of Clinical Sciences Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1994.tb04395.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.67.5.858"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","unstructured":"PelosoJG VoglerJB CohenND MarquisP&HiltLUse of standing MRI and a new MRI grading system of the subchondral bone of the distal third metacarpal bone to identify bone changes in the thoroughbred racehorse when comparing 21 cases of catastrophic biaxial proximal sesamoid bone fracture with 53 controls. 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