{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:22:51Z","timestamp":1787016171122,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the use and outcome of sclerotherapy with intralesional doxycycline foam in a horse with a mandibular aneurysmal bone cyst.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Case report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Client\u2010owned 1 year old Standardbred filly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The horse presented for progressive mandibular swelling. A 10\u00a0mg\/mL doxycycline foam was prepared for intralesional injection. Three doses were injected into the lesion under computed tomographic guidance at 6 and 15\u2009weeks after initial treatment. Volume reduction was monitored after each treatment with 3D volumetric rendering and region of interest segmentation using commercially available software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The volume of the lesion decreased from 458.7455\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      before treatment, to 363.3101\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      at 6\u2009weeks, 273.5855\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      at 15\u2009weeks, and 247.2316\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      6\u00a0months later, resulting in a total reduction of 54% of the initial volume. Bone formation was noted in the lesion. No adverse effects related to doxycycline foam injections were noted. The mandibular swelling was resolved after treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intralesional doxycycline sclerotherapy was shown to be efficacious in reducing the volume of the aneurysmal bone cyst in the horse presented in this report. There was complete resolution of mandibular swelling with no side effects related to the intralesional injections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vsu.13844","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T08:07:49Z","timestamp":1655885269000},"page":"1265-1272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Percutaneous doxycycline sclerotherapy in a horse with a mandibular aneurysmal bone cyst"],"prefix":"10.1111","volume":"51","author":[{"given":"Jairo A.","family":"Perez","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, New Bolton Center University of Pennsylvania Kennett Square Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy L.","family":"Weber","sequence":"additional","affiliation":[{"name":"Cancer Center and Division of Orthopedics at Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Bender","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, New Bolton Center University of Pennsylvania Kennett Square Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn B.","family":"Wulster","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, New Bolton Center University of Pennsylvania Kennett Square Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Parente","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, New Bolton Center University of Pennsylvania Kennett Square Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2011.12.002"},{"key":"e_1_2_7_3_1","first-page":"48","article-title":"Surgical treatment of an aneurysmal bone cyst in a dog","volume":"8","author":"Duval J","year":"1995","journal-title":"VCOT Arch"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojpathology.2016.62011"},{"key":"e_1_2_7_5_1","first-page":"179","article-title":"R Y: case report: congenital aneurysmal bone cyst in a Holstein calf","volume":"164","author":"Kilic N","year":"2013","journal-title":"Revue de m\u00e9decine v\u00e9t\u00e9rinaire"},{"key":"e_1_2_7_6_1","first-page":"570","article-title":"Multiple aneurysmal bone cysts in a foal","volume":"38","author":"Thomas HL","year":"1997","journal-title":"Can Vet J"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/jvet.2002.36014"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/9781119276715.ch7","volume-title":"Principles of Musculoskeletal Disease, in Adams and Stashak's Lameness in Horses","author":"McIlwraith CW","year":"2020"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.15.255"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.240.1.69"},{"key":"e_1_2_7_11_1","first-page":"57","article-title":"Aneurysmal bone cyst in the horse","volume":"72","author":"Steiner JV","year":"1982","journal-title":"Cornell Vet"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-013-3043-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.7.1086"},{"key":"e_1_2_7_15_1","first-page":"e13571","article-title":"Three\u2010dimensional volumetric assessment of resected gliomas assisted by Horos imaging software: video case series of postoperative tumor analyses","volume":"13","author":"Elsawaf Y","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1999.tb03835.x"},{"key":"e_1_2_7_17_1","unstructured":"EasleyJ.Equine dental developmental abnormalities Proceedings Focus Meeting. 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