{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:18Z","timestamp":1787016078005,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006070","name":"Society of Surgical Oncology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to describe the clinical features, prognostic factors, and outcomes in dogs with surgically treated salivary gland carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Multi\u2010institutional retrospective case series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Seventy\u2010two client\u2010owned dogs from 16 institutions with surgically excised salivary gland carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records of dogs undergoing sialoadenectomy from January 1, 2000 to January 1, 2020 were reviewed for signalment, clinical signs, preoperative staging results, preoperative mass evaluation, complications, histopathologic diagnosis, local recurrence, metastatic disease, and survival times. Survival functions were estimated using the Kaplan\u2010Meier estimator. Factors related to survival were individually tested using the log\u2010rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The overall median survival time (MST) associated with salivary carcinoma was 1886\u2009days. Local recurrence occurred in 29\/69 (42%) dogs with an overall disease\u2010free interval (DFI) of 191\u2009days. Metastatic disease occurred in 22\/69 (31.9%) dogs, with an overall DFI of 299\u2009days. Lymph node metastasis was present at the time of surgery in 11\/38 (28.9%) dogs in which lymphadenectomy was performed at the time of surgery; these dogs had a shorter DFI at 98\u2009days (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u2009.03) and MST at 248\u2009days (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prognosis for dogs with salivary gland carcinoma treated surgically was more favorable than previously reported. Nodal metastasis was a negative prognostic factor for canine salivary gland carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical significance<\/jats:title>\n                    <jats:p>Surgical intervention should be considered for dogs with salivary carcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vsu.13928","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:28:49Z","timestamp":1673915329000},"page":"370-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Outcomes and clinical features associated with surgically excised canine salivary gland carcinoma: A\n                    <scp>multi\u2010institutional<\/scp>\n                    , retrospective, Veterinary Society of Surgical Oncology study"],"prefix":"10.1111","volume":"52","author":[{"given":"Kaleigh M.","family":"Bush","sequence":"first","affiliation":[{"name":"Auburn University Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4554-8013","authenticated-orcid":false,"given":"Janet A.","family":"Grimes","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine University of Georgia Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1457-617X","authenticated-orcid":false,"given":"Daniel S.","family":"Linden","sequence":"additional","affiliation":[{"name":"First Coast Veterinary Specialists Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-6484","authenticated-orcid":false,"given":"Tanja","family":"Plavec","sequence":"additional","affiliation":[{"name":"IVC Evidensia Tierklinik Hofheim GmbH Hofheim am Taunus Germany"},{"name":"Small Animal Clinic, Veterinary Faculty, University of Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kessler","sequence":"additional","affiliation":[{"name":"IVC Evidensia Tierklinik Hofheim GmbH Hofheim am Taunus Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Rossanese","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services, The Royal Veterinary College Hatfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Bennett","sequence":"additional","affiliation":[{"name":"Auburn University Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Chadsey","sequence":"additional","affiliation":[{"name":"Department of Surgery, Animal Medical Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney S.","family":"Coggeshall","sequence":"additional","affiliation":[{"name":"Smiley Data Analytics Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad M.","family":"Matz","sequence":"additional","affiliation":[{"name":"Auburn University Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-37-5-478"},{"key":"e_1_2_7_3_1","first-page":"561","article-title":"Salivary\u2010gland tumors in dogs and cats \u2010 a literature and case review","volume":"24","author":"Carberry CA","year":"1988","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1997.tb03353.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.140.22.583"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.36-1-71"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2460\/javma.1991.198.03.465","article-title":"Salivary gland disease in dogs and cats: 245 cases (1985\u20131988)","volume":"198","author":"Spangler WL","year":"1991","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.228"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00449"},{"key":"e_1_2_7_10_1","first-page":"1653","volume-title":"Veterinary Surgery Small Animal","author":"Ritter MJ","year":"2018"},{"key":"e_1_2_7_11_1","first-page":"211","volume-title":"World Health Organisation Classification of Tumours. 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