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Response options were scored, and individual scores summed to give a total clinical severity score for each cat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Brachycephalic cats had more frequent snoring (odds ratio [OR] 6.89; 95% confidence interval [CI]: 5.06\u20139.41), sneezing (OR 6.52; CI: 4.75\u20138.98), nasal discharge (OR 8.26; 95% CI 5.77\u201311.85), coughing (OR 1.75; CI: 1.17\u20132.59), and dyspnea (OR 5.32; CI: 3.42\u20138.28); shorter activity before becoming dyspneic (OR 2.71; CI: 1.93\u20133.79), slower recovery from activity (OR 3.17; CI: 2.19\u20134.57), lower activity levels (OR 2.16; CI: 1.59\u20132.95), and increased respiratory noise (OR 6.68; CI: 4.71\u20139.52); and more hypersalivation (OR 2.50; CI: 1.47\u20134.16), halitosis (OR 1.40; CI: 1.00\u20131.95), and difficulty chewing (OR 5.19; CI: 3.65\u20137.38). Median clinical severity scores were higher for BC cats than non\u2010BC cats (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Brachycephalic cats (BC) were at risk for respiratory, gastrointestinal, and activity\u2010related symptoms compared to non\u2010BC cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical relevance<\/jats:title><jats:p>Some BC cats exhibit clinically relevant symptoms and behaviors as reported by owners. Medical or surgical interventions may improve these symptoms and warrant investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.13931","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T05:09:21Z","timestamp":1672376961000},"page":"435-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Influence of feline brachycephaly on respiratory, gastrointestinal, sleep, and activity abnormalities"],"prefix":"10.1111","volume":"52","author":[{"given":"Hadley E.","family":"Gleason","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Medicine, College of Veterinary Medicine University of Illinois  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3291-0266","authenticated-orcid":false,"given":"Heidi","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine, College of Veterinary Medicine University of Illinois  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4088-6902","authenticated-orcid":false,"given":"Annette M.","family":"McCoy","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine, College of Veterinary Medicine University of Illinois  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181928"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(92)50306-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.237.9.1048"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12447"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.5326\/0440243"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13302"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2011.00635.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130741"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-6281"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15547"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12734"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-6654"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638717703434"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2012.00941.x"},{"issue":"1","key":"e_1_2_7_16_1","first-page":"58","article-title":"Clinical assessment and C\u2010reactive protein (CRP), haptoglobin (hp), and cardiac troponin I (cTnI) values of brachycephalic dogs with upper airway obstruction before and after surgery","volume":"79","author":"Planellas M","year":"2015","journal-title":"Can J Vet Res"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.5326\/0460366"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12299"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.7120\/096272812X13345905673809"},{"key":"e_1_2_7_20_1","unstructured":"AKC Most Popular Breeds.https:\/\/www.akc.org\/most-popular-breeds\/. 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