{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T01:02:04Z","timestamp":1774314124980,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2023,7]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To determine the effect of flushing of the common bile duct (CBD) on hepatobiliary markers and short\u2010term outcome in dogs undergoing cholecystectomy for the management of gallbladder mucocele (GBM).<\/jats:p><\/jats:sec>Study design<\/jats:title>Randomized, controlled, prospective study.<\/jats:p><\/jats:sec>Animals<\/jats:title>Thirty\u2010two client\u2010owned dogs.<\/jats:p><\/jats:sec>Methods<\/jats:title>Dogs were allocated randomly to either a \u201cflush\u201d group or a \u201cnon\u2010flush group.\u201d Flushing was performed in a normograde fashion, followed by a routine cholecystectomy. Data collected included presenting clinical signs, preoperative and 3\u2010day postoperative hepatobiliary markers (alkaline phosphatase, ALP; alanine aminotransferase, ALT; gamma glumatyl\u2010transferase, GGT; bilirubin; cholesterol; triglycerides), duration of hospitalization, and complications. These data were compared between groups.<\/jats:p><\/jats:sec>Results<\/jats:title>Sixteen dogs were enrolled in each group. One dog (in the flush group) was excluded following diagnosis of hepatic lymphoma. Border terriers were overrepresented (20\/31). Overall, there were marked reductions from preoperative to 3\u2009days postoperative in serum bilirubin (p<\/jats:italic>\u2009=\u2009.004), ALP (p<\/jats:italic>\u2009=\u2009.020), ALT (p<\/jats:italic>\u2009<\u2009.001), GGT (p<\/jats:italic>\u2009=\u2009.025), and cholesterol (p<\/jats:italic>\u2009<\u2009.001) values. There was no difference in any marker between groups. Survival to discharge was 90.3% (28\/31 dogs).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Cholestatic markers decreased significantly 3\u2009days postcholecystectomy. No short\u2010term clinical or clinico\u2010pathological benefits were identified when flushing the CBD in dogs undergoing cholecystectomy for GBM.<\/jats:p><\/jats:sec>Clinical significance<\/jats:title>The findings of the study do not support routine flushing of the CBD during cholecystectomy for GBM in dogs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.13956","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T03:54:47Z","timestamp":1681358087000},"page":"697-703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The effect of flushing of the common bile duct on hepatobiliary markers and short\u2010term outcomes in dogs undergoing cholecystectomy for the management of gall bladder mucocele: A randomized controlled prospective study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7662-8601","authenticated-orcid":false,"given":"Tom L.","family":"Hernon","sequence":"first","affiliation":[{"name":"Langford Veterinary Services, Small Animal Hospital University of Bristol Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ed J.","family":"Friend","sequence":"additional","affiliation":[{"name":"Langford Veterinary Services, Small Animal Hospital University of Bristol Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7414-6403","authenticated-orcid":false,"given":"Guillaume","family":"Chanoit","sequence":"additional","affiliation":[{"name":"Langford Veterinary Services, Small Animal Hospital University of Bristol Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicki","family":"Black","sequence":"additional","affiliation":[{"name":"Langford Veterinary Services, Small Animal Hospital University of Bristol Bristol 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