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Postoperatively, dogs also received carprofen 2.2\u2009mg\/kg subcutaneously every 12\u2009h. Rescue analgesia was provided. Treatment success was defined as not requiring rescue analgesia over the 48\u2010h postoperative period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no difference between treatment success, postoperative opioid consumption, CMPS\u2010SF pain scores, or %BW<jats:sub>dist<\/jats:sub> in dogs that received surgical wound infiltration with LB compared with those receiving saline placebo, following TPLO. There was no linear correlation between CMPS\u2010SF pain scores and %BW<jats:sub>dist<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For the population of dogs that underwent TPLO and received postoperative carprofen at our institution, LB did not provide an analgesic effect discernable by success\/failure analysis, CMPS\u2010SF pain scores, or %BW<jats:sub>dist<\/jats:sub> measurement using a weight distribution platform, compared with saline placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance<\/jats:title><jats:p>LB may not provide detectable analgesia during the first 48\u2009h for dogs recovering from TPLO and receiving only postoperative carprofen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.13967","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T12:25:06Z","timestamp":1682684706000},"page":"721-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blinded, randomized, placebo\u2010controlled study of the efficacy of bupivacaine liposomal suspension using static bodyweight distribution and subjective pain scoring in dogs after tibial plateau leveling osteotomy surgery"],"prefix":"10.1111","volume":"52","author":[{"given":"Lauren A.","family":"Aldrich","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine Kansas State University  Manhattan Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7409-3957","authenticated-orcid":false,"given":"David A.","family":"Upchurch","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine Kansas State University  Manhattan Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James K.","family":"Roush","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine Kansas State University  Manhattan Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"U.S. Food and Drug Administration.Currently approved labels for veterinary non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs).https:\/\/animaldrugsatfda.fda.gov\/adafda\/views\/-\/nsaidLabels2021."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(08)70007-X"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12200"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2018.06.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2021.01.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12792"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.76.9.755"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.2006.00778.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12224"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.116.071902"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12140"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.236.7.751"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.14-0602"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-35-2-95"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(98)90151-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.1768"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.5326\/0400468"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2006.00302.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.legalmed.2010.03.001"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-publhealth-031914-122957"},{"key":"e_1_2_9_22_1","article-title":"Fatal transdermal fentanyl patch overdose in a child","volume":"12","author":"Hilado MA","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_9_23_1","unstructured":"EXPAREL.Prescribing information. 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